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Stat5 Inhibitor (CAS 285986-31-4) - chemical structure image
Stat5 Inhibitor 的分子结构, CAS编号: 285986-31-4
Stat5 Inhibitor (CAS 285986-31-4) - chemical structure image
Stat5 Inhibitor 的分子结构, CAS编号: 285986-31-4
Stat5 Inhibitor 的分子结构, CAS编号: 285986-31-4

Stat5 Inhibitor 抑制剂 (CAS 285986-31-4)

5.0(1)
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查看产品引用文献(36)

备用名:
Stat5 Inhibitor is known as a nonpetidic nicotinoyl hydrazone.
应用:
Stat5 Inhibitor 是一种细胞渗透性化合物，可选择性地靶向 Stat5 的 SH2 结构域（针对 STAT5b SH2 结构域 EPO 肽结合活性的 IC50 = 47 µM）。
CAS号码:
285986-31-4
纯度:
≥97%
分子量:
293.28
分子式:
C16H11N3O3
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).

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Stat5抑制剂是一种可渗透细胞的非肽烟酰腙，通过与SH2结构域结合来抑制STAT5。研究表明，Stat5抑制剂对STAT1和STAT3的SH2结构域的抑制程度低于对STAT5的抑制。此外，Stat5抑制剂抑制了K562核提取物中STAT5/STAT5 DNA的结合。STAT5在造血干细胞的稳态、血细胞的发育、生长激素的作用和乳腺上皮细胞的分化等过程中发挥生物学作用。Stat5抑制剂显示阻断了K562核提取物中STAT5/STAT5 DNA的结合活性，并抑制了IFN-α刺激的STAT5，但不会抑制Daudi细胞中STAT1或STAT3的酪氨酸磷酸化。


Stat5 Inhibitor 抑制剂 (CAS 285986-31-4) 参考文献

  1. 发现基于色酮的转录因子 STAT5 抑制剂。  |  Müller, J., et al. 2008. Chembiochem. 9: 723-7. PMID: 18247434
  2. STAT5 极化可促进 iTregs 并抑制人类 T 细胞异体反应，同时保留 CTL 能力。  |  Betts, BC., et al. 2014. J Leukoc Biol. 95: 205-13. PMID: 24068731
  3. Janus 激酶 2 对 Na+/K+-ATP 酶的能量敏感调控  |  Bhavsar, SK., et al. 2014. Am J Physiol Cell Physiol. 306: C374-84. PMID: 24304834
  4. 组蛋白 H1 和染色体蛋白 HMGN2 调控催乳素诱导的 STAT5 转录因子在乳腺癌细胞中的招募和功能  |  Schauwecker, SM., et al. 2017. J Biol Chem. 292: 2237-2254. PMID: 28035005
  5. 白细胞介素-7通过STAT5诱导破骨细胞形成，与NF-kappaB受体激活剂配体无关  |  Kim, JH., et al. 2017. Front Immunol. 8: 1376. PMID: 29104576
  6. 生长激素通过调节 FSP27 的表达来控制脂肪分解。  |  Sharma, R., et al. 2018. J Endocrinol. 239: 289-301. PMID: 30400015
  7. 磁共振成像：现状与未来展望。  |  Bydder, GM. 1988. Br J Radiol. 61: 889-97. PMID: 3056559
  8. Akt 和 STAT5 介导幼稚人 CD4+ T 细胞对 TCR 刺激的早期代谢反应。  |  Jones, N., et al. 2019. Nat Commun. 10: 2042. PMID: 31053703
  9. 肾脏分泌的促红细胞生成素通过激活脂肪组织中的 JAK2-STAT5 信号来降低血脂。  |  Li, J., et al. 2019. EBioMedicine. 50: 317-328. PMID: 31740386
  10. 抗CCL22可通过STAT5途径增加类风湿性关节炎患者CD4+T细胞中的调节性T细胞。  |  Wang, L., et al. 2020. Exp Ther Med. 19: 2127-2132. PMID: 32104275
  11. 催乳素反应性环状 RNA circHIPK3 促进奶牛乳腺上皮细胞增殖  |  Liu, J., et al. 2020. Genes (Basel). 11: PMID: 32245109
  12. CCL11 可增加 CD4+CD25+Foxp3+ Treg 细胞的比例，并通过 STAT5 信号通路增加 CD4+ T 细胞产生 IL-2 和 TGF-β。  |  Wang, R. and Huang, K. 2020. Mol Med Rep. 21: 2522-2532. PMID: 32323817
  13. CCL26 通过 STAT5 通路调节急性缺血性脑卒中后外周血单核细胞中 CD4+CD25+FOXP3+ Tregs 的比例和炎症因子的产生。  |  Dong, Z., et al. 2020. Exp Ther Med. 20: 3343-3351. PMID: 32855707
  14. 含多酚的马尾藻能抑制卵清蛋白致敏小鼠脾细胞的 Th2 分化：转录因子 GATA3/STAT5/NLRP3 参与了 Th2 极化。  |  Herath, KHINM., et al. 2021. Pharm Biol. 59: 1464-1472. PMID: 34726583
  15. 信号转导和转录激活因子 5 (STAT5) 结合位点的突变会降低山羊乳腺上皮细胞中牛奶过敏原 αS1-酪蛋白的含量。  |  Song, N., et al. 2022. Foods. 11: PMID: 35159497

订购信息

产品名称产品编号规格价格数量收藏夹

Stat5 Inhibitor, 10 mg

sc-355979
10 mg
$204.00

Stat5 Inhibitor, 100 mg

sc-355979A
100 mg
$1502.00

Is the compound soluble in ethanol or other solvent?

Asked by: Alex11
Thank you for your question. We do not have solubility data for this compound in ethanol or aqueous solutions. It is soluble in DMSO at a concentration of 25 mg/ml.
Answered by: Tech Support Europe
Date published: 2022-04-28

Can this inhibitor be administered in vivo using a mouse model?

Asked by: Jr555
Thank you for your question. We do not recommend or support the use of our chemicals for in vivo research applications. Our compounds are not pharmaceutical grade and not manufactured under GMP guidelines. Please consult your principal investigator and your animal care and use committee (ACUC) regarding the use of our compounds.
Answered by: Technical Support
Date published: 2021-05-17

Is Stat5 Inhibitor sterile?

Asked by: ChemSynth123
sc-355979 (Stat5 Inhibitor: CAS 285986-31-4) is not sterile.
Answered by: Chemical Support 7
Date published: 2017-06-12

What is the shelf life?

Asked by: chemsd02
Thank you for your question. sc-355979 (Stat5 Inhibitor, CAS 285986-31-4) has a shelf life of 2+ years when stored at 4°C. It is recommended to use solutions in the same day the are made.
Answered by: Chemical Support 10
Date published: 2017-03-08
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Rated 5 out of 5 by from LiaoLiao, Z. et al. (PMC 3056559) found that Stat5 Inhibitor (N'-((4-Oxo-4H-chromen-3-yl)methylene)nicotinohydrazide) was the most potent inhibitor of Stat5 with an IC50 of 47 M. -SCBT Publication Review
Date published: 2015-02-12
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Stat5 Inhibitor 抑制剂 is rated 5.0 out of 5 by 1.
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