Molecular structure of Stat3 Inhibitor VIII, 5,15-DPP, CAS Number: 22112-89-6
Stat3 Inhibitor VIII, 5,15-DPP (CAS 22112-89-6)
See product citations (6)
Alternate Names:
5,15-Diphenylporphyrin
Application:
Stat3 Inhibitor VIII, 5,15-DPP is a cell permeable Stat3 binding porphyrin
CAS Number:
22112-89-6
Purity:
>97%
Molecular Weight:
462.54
Molecular Formula:
C32H22N4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Stat3 Inhibitor VIII, 5,15-DPP is a cell-permeable porphyrin compound that binds Stat3 (STAT3, KD = 880 nM by SPR) and prevents Stat3 SH2 domain-mediated ligand binding (IC50 = 280 nM) and dimerization (~60% inhibition at 50 muM in HEK293), while exhibiting much reduced activity against STAT1 ligand binding (IC50 = 10 muM) and no activity againt Grb2 ligand binding even at concentrations as high as 20 muM. Stat3 Inhibitor VIII, 5,15-DPP pre-treatment (50 muM) of MDA-MB-468 cultures is shown to greatly inhibit IL-6-induced Stat3, but not STAT1/5a/5b, nuclear translocation (by >90%) and nuclear Stat3 c-myc promoter binding activity, resulting in a more than 90% reduction in cellular c-myc protein level.
Stat3 Inhibitor VIII, 5,15-DPP (CAS 22112-89-6) References
- Meso-porphyrinylphosphine oxides: mono- and bidentate ligands for supramolecular chemistry and the crystal structures of monomeric {[10,20-diphenylporphyrinatonickel(II)-5,15-diyl]-bis-[P(O)Ph(2)] and polymeric self-coordinated {[10,20-diphenylporphyrinatozinc(II)-5,15-diyl]-bis-[P(O)Ph(2)]}. | Atefi, F., et al. 2006. Inorg Chem. 45: 6479-89. PMID: 16878962
- Photodynamic effects of novel 5,15-diaryl-tetrapyrrole derivatives on human colon carcinoma cells. | Gariboldi, MB., et al. 2009. Bioorg Med Chem. 17: 2009-16. PMID: 19211252
- Novel high-throughput screening system for identifying STAT3-SH2 antagonists. | Uehara, Y., et al. 2009. Biochem Biophys Res Commun. 380: 627-31. PMID: 19285012
- Kinome profiling of non-canonical TRAIL signaling reveals RIP1-Src-STAT3-dependent invasion in resistant non-small cell lung cancer cells. | Azijli, K., et al. 2012. J Cell Sci. 125: 4651-61. PMID: 22797920
- Micro- or nanorod and nanosphere structures derived from a series of phenyl-porphyrins. | Reddy, MH., et al. 2014. Phys Chem Chem Phys. 16: 4386-93. PMID: 24458009
- Single-Molecule Investigations of Conformation Adaptation of Porphyrins on Surfaces. | Zhang, Q., et al. 2017. J Phys Chem Lett. 8: 1241-1247. PMID: 28248110
- Competition between Dehydrogenative Organometallic Bonding and Covalent Coupling of an Unfunctionalized Porphyrin on Cu(111). | Xiang, F., et al. 2018. ACS Nano. 12: 1203-1210. PMID: 29336554
- Transcriptional repression of human epidermal growth factor receptor 2 by ClC-3 Cl- /H+ transporter inhibition in human breast cancer cells. | Fujimoto, M., et al. 2018. Cancer Sci. 109: 2781-2791. PMID: 29949674
- A Supramolecular Approach for Modulated Photoprotection, Lysosomal Delivery, and Photodynamic Activity of a Photosensitizer. | Roy, I., et al. 2019. J Am Chem Soc. 141: 12296-12304. PMID: 31256588
- Weak Interactions and Conformational Changes in Core-Protonated A2- and Ax-Type Porphyrin Dications. | Kingsbury, CJ., et al. 2020. Molecules. 25: PMID: 32668713
- The commercially available STAT3 inhibitor 5,15-diphenylporphyrin (5,15-DPP) does not directly interact with STAT3 core residues 127-722. | Mtwebana, SS. and Prinsloo, E. 2020. BMC Res Notes. 13: 345. PMID: 32690111
- Host-Guest Complexation-Mediated Supramolecular Photon Upconversion. | Roy, I., et al. 2020. J Am Chem Soc. 142: 16600-16609. PMID: 32865399
- Synthesis of meso-pyrrole-substituted corroles by condensation of 1,9-diformyldipyrromethanes with pyrrole. | Temelli, B. and Kapci, P. 2022. Beilstein J Org Chem. 18: 1403-1409. PMID: 36262669
Inhibitor of:
SH2D, Stat3, and Transcription Factor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Stat3 Inhibitor VIII, 5,15-DPP, 25 mg | sc-204305 | 25 mg | $137.00 |