Molecular structure of STAT3 Inhibitor VII, CAS Number: 1041438-68-9
STAT3 Inhibitor VII (CAS 1041438-68-9)
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Application:
STAT3 Inhibitor VII is a cellular JAK1/JAK2/TYK2/STAT3 activation inhibitor
CAS Number:
1041438-68-9
Purity:
≥95%
Molecular Weight:
444.26
Molecular Formula:
C19H7F7N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
STAT3 Inhibitor VII is a cell permeable dihydroquinoline that specifically inhibits JAK1, JAK2, TYK2, and STAT3. This pathway is important in cell proliferation and so this inhibitor is ideal to inhibit cell proliferation in cancer cells. STAT3 is part of the STAT family of proteins which are readily phosphorylated by receptor-associated kinases. Upon activation STAT proteins induce transcription factors. Studies involving IFNgamma-activated human astrocytes indicate that STAT3 inhibitors can attenuate neutoxicity and inflammatory molecule production. In addition, studies suggest that STAT3 Inhibitor VII is an active suppressor of IL-23-induced expression of IL-23 receptor subunits in human SUPT-1T cells and in primary CD4 human T cells.
STAT3 Inhibitor VII (CAS 1041438-68-9) References
- Inhibition of the signal transducer and activator of transcription-3 (STAT3) signaling pathway by 4-oxo-1-phenyl-1,4-dihydroquinoline-3-carboxylic acid esters. | Xu, J., et al. 2008. J Med Chem. 51: 4115-21. PMID: 18578470
- The neurosurvival factor Humanin inhibits beta-cell apoptosis via signal transducer and activator of transcription 3 activation and delays and ameliorates diabetes in nonobese diabetic mice. | Hoang, PT., et al. 2010. Metabolism. 59: 343-9. PMID: 19800083
- STAT3 inhibitors attenuate interferon-γ-induced neurotoxicity and inflammatory molecule production by human astrocytes. | Hashioka, S., et al. 2011. Neurobiol Dis. 41: 299-307. PMID: 20888416
- Interleukin-23-induced interleukin-23 receptor subunit expression is mediated by the Janus kinase/signal transducer and activation of transcription pathway in human CD4 T cells. | Che Mat, NF., et al. 2011. J Interferon Cytokine Res. 31: 363-71. PMID: 21138378
- Hepatic stellate cells undermine the allostimulatory function of liver myeloid dendritic cells via STAT3-dependent induction of IDO. | Sumpter, TL., et al. 2012. J Immunol. 189: 3848-58. PMID: 22962681
- Overcoming cancer cell resistance to VSV oncolysis with JAK1/2 inhibitors. | Escobar-Zarate, D., et al. 2013. Cancer Gene Ther. 20: 582-9. PMID: 24030211
- STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis. | Sun, Y., et al. 2015. Neuropathol Appl Neurobiol. 41: 347-70. PMID: 24606160
- STAT3 contributes to NK cell recognition by modulating expression of NKG2D ligands in adriamycin-resistant K562/AO2 cells. | Cai, X., et al. 2015. Int J Hematol. 102: 536-43. PMID: 26387089
- Matrine increases NKG2D ligand ULBP2 in K562 cells via inhibiting JAK/STAT3 pathway: a potential mechanism underlying the immunotherapy of matrine in leukemia. | Lu, X., et al. 2015. Am J Transl Res. 7: 1838-49. PMID: 26692928
- Mechanosensor polycystin-1 potentiates differentiation of human osteoblastic cells by upregulating Runx2 expression via induction of JAK2/STAT3 signaling axis. | Dalagiorgou, G., et al. 2017. Cell Mol Life Sci. 74: 921-936. PMID: 27699453
- Osteopontin production by TM4SF4 signaling drives a positive feedback autocrine loop with the STAT3 pathway to maintain cancer stem cell-like properties in lung cancer cells. | Choi, SI., et al. 2017. Oncotarget. 8: 101284-101297. PMID: 29254164
- Tescalcin/c-Src/IGF1Rβ-mediated STAT3 activation enhances cancer stemness and radioresistant properties through ALDH1. | Lee, JH., et al. 2018. Sci Rep. 8: 10711. PMID: 30013043
- Computer-aided prediction of inhibitors against STAT3 for managing COVID-19 associated cytokine storm. | Dhall, A., et al. 2021. Comput Biol Med. 137: 104780. PMID: 34450382
Inhibitor of:
Stat3, and Transcription Factor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
STAT3 Inhibitor VII, 5 mg | sc-355978 | 5 mg | $296.00 |