Molecular structure of ST638, CAS Number: 107761-24-0
ST638 (CAS 107761-24-0)
Alternate Names:
2- cyano- 3- [3- ethoxy- 4- hydroxy- 5- [(5- phenylthio)methyl]phenyl]- 2- propenamide
Application:
ST638 is a protein tyrosine kinase inhibitor and PLD inhibitor
CAS Number:
107761-24-0
Molecular Weight:
354.42
Molecular Formula:
C19H18N2O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Protein tyrosine kinase inhibitor (IC50 = 370 nM) that also inhibits HGF-induced MAP kinase activation in hepatocytes. Also shown to inhibit phospholipase D activity in human neutrophils. Decreases the O2· production induced by pervanadate in guinea pig neutrophils.
ST638 (CAS 107761-24-0) References
- Zymosan-triggered tyrosine phosphorylation in mouse bone-marrow-derived macrophages is enhanced by respiratory-burst priming agents. | Green, SP., et al. 1992. Biochem J. 288 (Pt 2): 427-32. PMID: 1281405
- Modulation of TNF-alpha-priming and stimulation-dependent superoxide generation in human neutrophils by protein kinase inhibitors. | Utsumi, T., et al. 1992. Arch Biochem Biophys. 294: 271-8. PMID: 1312809
- Tyrosine phosphorylation is involved in receptor coupling to phospholipase D but not phospholipase C in the human neutrophil. | Uings, IJ., et al. 1992. Biochem J. 281 (Pt 3): 597-600. PMID: 1371383
- Thrombin-induced human platelet aggregation is inhibited by protein-tyrosine kinase inhibitors, ST638 and genistein. | Asahi, M., et al. 1992. FEBS Lett. 309: 10-4. PMID: 1511739
- Transduction of a signal for arachidonic acid metabolism by untriggered CSF-1 receptor induces an opposite effect to that induced by CSF-1 receptor and its ligand: separate regulation of phospholipase A2 and cyclooxygenase by CSF-1 receptor/CSF-1. | Puri, J., et al. 1992. Prostaglandins Leukot Essent Fatty Acids. 45: 43-8. PMID: 1532099
- Granulocyte-macrophage colony-stimulating factor induces a staurosporine inhibitable tyrosine phosphorylation of unique neutrophil proteins. | Berkow, RL. 1992. Blood. 79: 2446-54. PMID: 1571555
- Peroxides of vanadate induce activation of phospholipase D in HL-60 cells. Role of tyrosine phosphorylation. | Bourgoin, S. and Grinstein, S. 1992. J Biol Chem. 267: 11908-16. PMID: 1601860
- Selective inhibition of PGE2 production in cells transfected with c-fms encoded CSF-1 receptor genes by the tyrosine kinase inhibitor, ST638. | Puri, J., et al. 1991. Agents Actions. 33: 314-7. PMID: 1950818
- Inhibitors for protein-tyrosine kinases, ST638 and genistein: induce differentiation of mouse erythroleukemia cells in a synergistic manner. | Watanabe, T., et al. 1989. Exp Cell Res. 183: 335-42. PMID: 2767154
- Respiratory burst and tyrosine phosphorylation by vanadate. | Yamaguchi, M., et al. 1995. Arch Biochem Biophys. 323: 382-6. PMID: 7487102
- Effects of herbimycin A and ST638 on Fc epsilon receptor-mediated histamine release and Ca2+ signals in rat basophilic leukemia (RBL-2H3) cells. | Teshima, R., et al. 1994. Biochim Biophys Acta. 1221: 37-46. PMID: 7510521
- Mitogen-activated protein kinase activation in hepatocyte growth factor-stimulated rat hepatocytes: involvement of protein tyrosine kinase and protein kinase C. | Adachi, T., et al. 1996. Hepatology. 23: 1244-53. PMID: 8621160
- Effects of protein tyrosine kinase inhibitors on contractility of isolated bronchioles of the rat. | Chopra, LC., et al. 1997. Am J Respir Cell Mol Biol. 16: 372-8. PMID: 9115747
Inhibitor of:
PC-PLD, and Tyrosine Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ST638, 5 mg | sc-202344 | 5 mg | $121.00 |