ST638 CAS: 107761-24-0
MF: C19H18N2O3S
MW: 354.42
A protein tyrosine kinase inhibitor and PLD inhibitor.

ST638 (CAS 107761-24-0)

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Synonym: 2- cyano- 3- [3- ethoxy- 4- hydroxy- 5- [(5- phenylthio)methyl]phenyl]- 2- propenamide
Application: A protein tyrosine kinase inhibitor and PLD inhibitor
CAS Number: 107761-24-0
Molecular Weight: 354.42
Molecular Formula: C19H18N2O3S
* Refer to Certificate of Analysis for lot specific data (including water content).
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ST638 is a protein tyrosine kinase inhibitor (IC50 = 370 nM) that also inhibits HGF-induced MAP kinase activation in hepatocytes. ST638 has also shown to inhibit PC-PLD (phospholipase D) activity in human neutrophils. This product decreases the O2⋅ production induced by pervanadate in neutrophils.


References

Adachi, T., et al. 1996. Hepatology 23, 1244. Yamaguchi, M., et al. 1995. Arch. Biochem. Biophys. 323, 382. Uings, I., et al. 1992. Biochem. J. 281, 597. Shiraishi, T., et al. 1988. Chem. Pharm. Bull. 36, 974.

Physical State :
Solid
Solubility :
Soluble in DMF, and DMSO (19 mg/ml).
Storage :
Store at -20° C
Melting Point :
134-135.5° C
Boiling Point :
611.24° C at 760 mmHg
Density :
1.32 g/cm3
Refractive Index :
n20D 1.66
IC50 :
Protein tyrosine kinase: IC50 = 0.37 µM; Epidermal growth factor receptor erbB1: IC50 = 0.4 µM (human)
pK Values :
pKa: 9.06
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
UC6316200
PubChem CID :
5941457
MDL Number :
MFCD00236446
SMILES :
CCOC1=CC(=CC(=C1O)CSC2=CC=CC=C2)C=C(C#N)C(=O)N

Download SDS (MSDS)

Certificate of Analysis

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