St3Gal-IV Antibody (1F4): sc-293406

St3Gal-IV Antibody (1F4) is a mouse monoclonal IgG1 kappa light chain antibody that detects St3Gal-IV protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-St3Gal-IV antibody (1F4) is available as a non-conjugated format, providing researchers with a reliable tool for studying this important protein. St3Gal-IV, also known as SIAT4-C or SI4C, plays a crucial role in the biosynthesis of sialylated glycans, which are essential for various cellular processes, including cell-cell interactions and signaling. Located primarily in the Golgi apparatus, St3Gal-IV adds sialic acid in an alpha2,3 linkage to glycoproteins and glycolipids, thereby influencing the structural diversity of cell surface carbohydrates. This modification is vital for the formation of selectin ligands, which are involved in leukocyte trafficking and the inflammatory response. St3Gal-IV expression is significantly elevated in brain tissues, highlighting a potential role in neurobiology. Research indicates that down-regulation of St3Gal-IV expression is associated with the malignant progression of human renal cell carcinoma, suggesting potential as a biomarker for cancer progression and a target for therapeutic intervention.

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St3Gal-IV Antibody (1F4) References:

1. Clinical significance of ST3Gal IV expression in human renal cell carcinoma.  |  Saito, S., et al. 2002. Oncol Rep. 9: 1251-5. PMID: 12375029
2. Sialyltransferase specificity in selectin ligand formation.  |  Ellies, LG., et al. 2002. Blood. 100: 3618-25. PMID: 12393657
3. Region-specific and epileptogenic-dependent expression of six subtypes of alpha2,3-sialyltransferase in the adult mouse brain.  |  Matsuhashi, H., et al. 2003. J Neurochem. 84: 53-66. PMID: 12485401
4. Three genes that encode human beta-galactoside alpha 2,3-sialyltransferases. Structural analysis and chromosomal mapping studies.  |  Chang, ML., et al. 1995. Glycobiology. 5: 319-25. PMID: 7655169
5. Genomic organization and chromosomal mapping of the Gal beta 1,3GalNAc/Gal beta 1,4GlcNAc alpha 2,3-sialyltransferase.  |  Kitagawa, H., et al. 1996. J Biol Chem. 271: 931-8. PMID: 8557707

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-St3Gal-IV Antibody (1F4) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-St3Gal-IV Antibody (1F4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

St3Gal-IV Antibody (1F4) Specifications

Alternate Product Name: St3Gal-IV

Product Clone Name: 1F4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 31-130

Epitope Target: St3Gal-IV

Epitope Species: human

Product Reactivity/Detection: St3Gal-IV

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for St3Gal-IV Antibody (1F4): N/A