Molecular structure of ST 91, CAS Number: 4749-61-5
ST 91 (CAS 4749-61-5)
Alternate Names:
2-(2,6-Diethylphenylamino)-2-imidazoline hydrochloride; 2-IMIDAZOLINE, 2-(2,6-DIETHYLANILINO)-, HYDROCHLORIDE; N-(2,6-Diethylphenyl)-4,5-dihydro-1H-imidazol-2-amine hydrochloride
Application:
ST 91 is an α2-adrenoceptor agonist
CAS Number:
4749-61-5
Molecular Weight:
253.77
Molecular Formula:
C13H19N3•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
ST 91 is an α2-AR (α2-adrenoceptor) an antinociceptive agonist that does not cross the blood brain barrier. Putative α2C agonist. Displays ~ 120-fold selectivity for α2 receptors over α1 receptors and acts predominantly at non-α2A-adrenoceptors which may be of the α2C subtype.
ST 91 (CAS 4749-61-5) References
- Cardiopulmonary effects of the alpha2-adrenoceptor agonists medetomidine and ST-91 in anesthetized sheep. | Celly, CS., et al. 1999. J Pharmacol Exp Ther. 289: 712-20. PMID: 10215644
- Synergistic interactions between two alpha(2)-adrenoceptor agonists, dexmedetomidine and ST-91, in two substrains of Sprague-Dawley rats. | Graham, BA., et al. 2000. Pain. 85: 135-43. PMID: 10692612
- Relationship between activity and structure in derivatives of clonidine. | Hoefke, W., et al. 1975. Arzneimittelforschung. 25: 786-93. PMID: 1242325
- Characterization of the pharmacology of intrathecally administered alpha-2 agonists and antagonists in rats. | Takano, Y. and Yaksh, TL. 1992. J Pharmacol Exp Ther. 261: 764-72. PMID: 1349648
- Some cardiovascular effects of ST-91 and clonidine. | Scriabine, A., et al. 1977. Eur J Pharmacol. 43: 333-41. PMID: 18355
- Demonstration of intrathecal and systemic morphine and ST-91 effects on fed canine upper gut motility. | Thomforde, GM., et al. 1990. Dig Dis Sci. 35: 1249-56. PMID: 1976496
- The effects of B-HT 920 and St 91 on venous haemodynamics in cats. | Widdop, RE. 1989. J Pharm Pharmacol. 41: 55-6. PMID: 2565967
- Spinal vs. supraspinal sites of action of the alpha 2-adrenergic agonists clonidine and ST-91 on the acoustic startle reflex. | Davis, M., et al. 1989. Pharmacol Biochem Behav. 33: 233-40. PMID: 2571168
- Chronic spinal infusion of dexmedetomidine, ST-91 and clonidine: spinal alpha 2 adrenoceptor subtypes and intrinsic activity. | Takano, Y. and Yaksh, TL. 1993. J Pharmacol Exp Ther. 264: 327-35. PMID: 8093729
- Pharmacology of the spinal action of ketorolac, morphine, ST-91, U50488H, and L-PIA on the formalin test and an isobolographic analysis of the NSAID interaction. | Malmberg, AB. and Yaksh, TL. 1993. Anesthesiology. 79: 270-81. PMID: 8102041
- Differential effects of two intraventricularly injected alpha 2 agonists, ST-91 and dexmedetomidine, on electroencephalogram, feeding, and electromyogram. | Dowlatshahi, P. and Yaksh, TL. 1997. Anesth Analg. 84: 133-8. PMID: 8989014
- Clonidine and ST-91 may activate imidazoline binding sites in the heart to release atrial natriuretic peptide. | Mukaddam-Daher, S., et al. 1997. Hypertension. 30: 83-7. PMID: 9231825
- Cardiopulmonary effects of clonidine, diazepam and the peripheral alpha 2 adrenoceptor agonist ST-91 in conscious sheep. | Celly, CS., et al. 1997. J Vet Pharmacol Ther. 20: 472-8. PMID: 9430771
Activator of:
alpha2C-AR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ST 91, 10 mg | sc-203703 | 10 mg | $135.00 | |||
ST 91, 50 mg | sc-203703A | 50 mg | $570.00 |