Molecular structure of ST 1936 oxalate, CAS Number: 1210-81-7
ST 1936 oxalate (CAS 1782228-83-4)
Application:
ST 1936 oxalate is a potent and selective agonist of the 5-HT6 receptor
CAS Number:
1782228-83-4
Purity:
≥98%
Molecular Weight:
326.78
Molecular Formula:
C13H17ClN2•C2H2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
ST 1936 oxalate is a compound that functions as a selective and potent antagonist of the 5-HT6 receptor. It acts by binding to the 5-HT6 receptor and inhibiting its activation by serotonin. This interaction modulates the release of neurotransmitters such as dopamine and norepinephrine. By blocking the 5-HT6 receptor, ST 1936 oxalate has the potential to affect cognitive function and memory processes. Its mechanism of action involves interfering with the signaling pathways associated with the 5-HT6 receptor, which may have implications for neurological disorders and cognitive function. ST 1936 oxalate′s mechanism of action at the molecular level involves its specific interaction with the 5-HT6 receptor, influencing neurotransmitter release and signaling within the central nervous system.
ST 1936 oxalate (CAS 1782228-83-4) References
- A microdialysis study of ST1936, a novel 5-HT6 receptor agonist. | Valentini, V., et al. 2011. Neuropharmacology. 60: 602-8. PMID: 21185318
- Behavioral pharmacology: potential antidepressant and anxiolytic properties. | Wesołowska, A. and Jastrzębska-Więsek, M. 2011. Int Rev Neurobiol. 96: 49-71. PMID: 21329784
- ST1936 stimulates cAMP, Ca2+, ERK1/2 and Fyn kinase through a full activation of cloned human 5-HT6 receptors. | Riccioni, T., et al. 2011. Eur J Pharmacol. 661: 8-14. PMID: 21549693
- Activation of 5-HT6 receptors inhibits corticostriatal glutamatergic transmission. | Tassone, A., et al. 2011. Neuropharmacology. 61: 632-7. PMID: 21619890
- Effects of the 5-HT(6) receptor agonist ST 1936 on depression- and anhedonia-like experimental models. | Scheggi, S., et al. 2011. Behav Brain Res. 224: 35-43. PMID: 21645553
- The serotonin-6 receptor as a novel therapeutic target. | Yun, HM. and Rhim, H. 2011. Exp Neurobiol. 20: 159-68. PMID: 22355260
- Evidence for a role of a dopamine/5-HT6 receptor interaction in cocaine reinforcement. | Valentini, V., et al. 2013. Neuropharmacology. 65: 58-64. PMID: 22982249
- Effects of ST1936, a selective serotonin-6 agonist, on electrical activity of putative mesencephalic dopaminergic neurons in the rat brain. | Borsini, F., et al. 2015. J Psychopharmacol. 29: 802-11. PMID: 25735994
- 5-HT6 Receptor Antagonists: Potential Efficacy for the Treatment of Cognitive Impairment in Schizophrenia. | de Bruin, NM. and Kruse, CG. 2015. Curr Pharm Des. 21: 3739-59. PMID: 26044973
- Antidepressant-like activity of EMD 386088, a 5-HT6 receptor partial agonist, following systemic acute and chronic administration to rats. | Jastrzębska-Więsek, M., et al. 2015. Naunyn Schmiedebergs Arch Pharmacol. 388: 1079-88. PMID: 26077660
- Study of a mechanism responsible for potential antidepressant activity of EMD 386088, a 5-HT6 partial agonist in rats. | Jastrzębska-Więsek, M., et al. 2016. Naunyn Schmiedebergs Arch Pharmacol. 389: 839-49. PMID: 27106213
- DREADD Modulation of Transplanted DA Neurons Reveals a Novel Parkinsonian Dyskinesia Mechanism Mediated by the Serotonin 5-HT6 Receptor. | Aldrin-Kirk, P., et al. 2016. Neuron. 90: 955-68. PMID: 27161524
- Peripheral serotonin-mediated system suppresses bone development and regeneration via serotonin 6 G-protein-coupled receptor. | Yun, HM., et al. 2016. Sci Rep. 6: 30985. PMID: 27581523
- 5-Hydroxytryptamine 6 Receptor (5-HT6R)-Mediated Morphological Changes via RhoA-Dependent Pathways. | Rahman, MA., et al. 2017. Mol Cells. 40: 495-502. PMID: 28681593
- A tricyclic antidepressant, amoxapine, reduces amyloid-β generation through multiple serotonin receptor 6-mediated targets. | Li, X., et al. 2017. Sci Rep. 7: 4983. PMID: 28694424
Activator of:
SR-6.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ST 1936 oxalate, 1 mg | sc-364625 | 1 mg | $158.00 | |||
| US: Only available in the US | ||||||
ST 1936 oxalate, 10 mg | sc-364625A | 10 mg | $306.00 | |||
| US: Only available in the US | ||||||