SSR 146977 hydrochloride CAS: 264618-44-2
MF: C35H42Cl2N4O2•HCl
MW: 658.10
A selective and potent NK3 receptor antagonist.

SSR 146977 hydrochloride (CAS 264618-44-2)

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Application: SSR 146977 hydrochloride is a selective and potent NK3 receptor antagonist
CAS Number: 264618-44-2
Molecular Weight: 658.10
Molecular Formula: C35H42Cl2N4O2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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SSR 146977 hydrochloride is a selective and potent NK3 receptor antagonist.

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), and ethanol (100 mM).
Storage :
Store at 4° C
Optical Activity :
α20D +23.6°, c = 1 in methanol
IC50 :
Senktide-induced inositol monophosphate formation and intracellular calcium mobilization: IC50 = 10 nM
Ki Data :
NK-3R: Ki= 0.26 nM (CHO cells expressing the human NK3 receptor ); NK-3R: Ki= 19.3 nM (CHO cells expressing the human NK2 receptor )
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
SMILES :
CN(C)C(=O)NC1(CCN(CC1)CCC[[email protected]@]2(CCCN(C2)C(=O)c3ccccc3)c4ccc(c(c4)Cl)Cl)c5ccccc5.Cl

Download SDS (MSDS)

Certificate of Analysis

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