Src Family Activator
See product citations (16)
Alternate Names:
YEEI phosphopeptide; EPQpYEEIPIYL; YEEI peptide
Application:
Src Family Activator is a synthetic activator for Src family members
Purity:
≥96%
Molecular Weight:
1473.7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Src Family Activator is a synthetic activator for Src family members. YEE1 phosphopeptide. Sequence derived from hamster polyoma virus middle T antigen inclusive of phosphorylated Tyr 324. Activates Src family members by binding to SH2 domains.
Src Family Activator References
- The role of backbone motions in ligand binding to the c-Src SH3 domain. | Wang, C., et al. 2001. J Mol Biol. 313: 873-87. PMID: 11697910
- Hierarchy of simulation models in predicting structure and energetics of the Src SH2 domain binding to tyrosyl phosphopeptides. | Verkhivker, GM., et al. 2002. J Med Chem. 45: 72-89. PMID: 11754580
- Inhibitory effects of rosmarinic acid on Lck SH2 domain binding to a synthetic phosphopeptide. | Ahn, SC., et al. 2003. Planta Med. 69: 642-6. PMID: 12898421
- The relationship between the pY+3 amino acid in the phosphopeptide ligands and the specificity for various SH2 domains. | Lee, KH. and Park, SH. 2004. Protein Pept Lett. 11: 527-32. PMID: 15579120
- Surface plasmon resonance thermodynamic and kinetic analysis as a strategic tool in drug design. Distinct ways for phosphopeptides to plug into Src- and Grb2 SH2 domains. | de Mol, NJ., et al. 2005. J Med Chem. 48: 753-63. PMID: 15689159
- Identification of novel fragment compounds targeted against the pY pocket of v-Src SH2 by computational and NMR screening and thermodynamic evaluation. | Taylor, JD., et al. 2007. Proteins. 67: 981-90. PMID: 17393456
- Engineered SH2 domains with tailored specificities and enhanced affinities for phosphoproteome analysis. | Veggiani, G., et al. 2019. Protein Sci. 28: 403-413. PMID: 30431205
- Revisiting the phosphotyrosine binding pocket of Fyn SH2 domain led to the identification of novel SH2 superbinders. | Li, S., et al. 2021. Protein Sci. 30: 558-570. PMID: 33314411
- Rapid T-cell receptor-mediated tyrosine phosphorylation of p120, an Fyn/Lck Src homology 3 domain-binding protein. | Reedquist, KA., et al. 1994. Proc Natl Acad Sci U S A. 91: 4135-9. PMID: 7514295
- Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck. | Eck, MJ., et al. 1993. Nature. 362: 87-91. PMID: 7680435
- SH2 domains recognize specific phosphopeptide sequences. | Songyang, Z., et al. 1993. Cell. 72: 767-78. PMID: 7680959
- Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms. | Waksman, G., et al. 1993. Cell. 72: 779-90. PMID: 7680960
- Activation of endogenous c-Src or a related tyrosine kinase by intracellular (pY)EEI peptide increases voltage-operated calcium channel currents in rabbit ear artery cells. | Wijetunge, S. and Hughes, AD. 1996. FEBS Lett. 399: 63-6. PMID: 8980120
- Dual specificity of Src homology 2 domains for phosphotyrosine peptide ligands. | Gay, B., et al. 1997. Biochemistry. 36: 5712-8. PMID: 9153411
- The phosphopeptide-binding specificity of Src family SH2 domains. | Payne, G., et al. 1994. Chem Biol. 1: 99-105. PMID: 9383377
Activator of:
SRC.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Src Family Activator, 0.5 mg | sc-3052 | 0.5 mg | $97.00 |