Srb7 Antibody (31-C): sc-101186

Srb7 Antibody (31-C) is a mouse monoclonal IgG1 kappa light chain antibody that detects Srb7 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Srb7 (31-C) antibody is available as the non-conjugated anti-Srb7 monoclonal isotype antibody. Srb7 protein plays a crucial role in transcription regulation within mammalian cells, functioning as a key component of high molecular weight coactivating complexes that facilitate communication between transcriptional activators and RNA polymerase II. Srb7 is part of the SMCC (SRB and MED protein cofactor complex), which is essential for enhancing gene-specific activation or repression by DNA-binding transcription factors. This complex includes Srb7 and other important proteins such as Med6 and Med7, which interact with coactivator proteins from the TRAP and DRIP complexes to promote steroid receptor-dependent transcriptional activation. SMCC association with PC4 (positive cofactor 4) allows for basal transcription repression independently of RNA polymerase II activity, highlighting Srb7′s multifaceted role in gene regulation. Anti-Srb7 antibody (31-C) versatility in various applications makes this reagent an invaluable tool for researchers studying transcriptional mechanisms in different species.

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Srb7 Antibody (31-C) References:

1. A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation.  |  Gu, W., et al. 1999. Mol Cell. 3: 97-108. PMID: 10024883
2. Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators.  |  Ito, M., et al. 1999. Mol Cell. 3: 361-70. PMID: 10198638
3. Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex.  |  Rachez, C., et al. 1999. Nature. 398: 824-8. PMID: 10235266
4. A dynamic model for PC4 coactivator function in RNA polymerase II transcription.  |  Malik, S., et al. 1998. Proc Natl Acad Sci U S A. 95: 2192-7. PMID: 9482861
5. Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways.  |  Jiang, YW., et al. 1998. Proc Natl Acad Sci U S A. 95: 8538-43. PMID: 9671713
6. The human homologue of Drosophila TRF-proximal protein is associated with an RNA polymerase II-SRB complex.  |  Xiao, H., et al. 1999. J Biol Chem. 274: 3937-40. PMID: 9933582

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Srb7 Antibody (31-C) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-Srb7 Antibody (31-C) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Srb7 Antibody (31-C) Specifications

Alternate Product Name: Srb7

Product Clone Name: 31-C

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-145

Epitope Target: Srb7

Epitope Species: human

Product Reactivity/Detection: Srb7

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for Srb7 Antibody (31-C): N/A