Molecular structure of SR 95531 Hydrobromide, CAS Number: 104104-50-9
SR 95531 Hydrobromide (CAS 104104-50-9)
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Alternate Names:
Gabazine; 6-imino-3-(4-methoxyphenyl)-1(6H)-pyridazinebutanoic acid, monohydrobromide
Application:
SR 95531 Hydrobromide is a selective GABAA receptor antagonist
CAS Number:
104104-50-9
Purity:
≥98%
Molecular Weight:
368.23
Molecular Formula:
C15H17N3O3•HBr
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
SR 95531 Hydrobromide is a chemical that functions as a selective antagonist of GABAA receptors. It acts by binding to the GABAA receptor and competitively inhibiting the action of gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the central nervous system. By blocking the GABAA receptor, SR 95531 Hydrobromide prevents the influx of chloride ions, which in turn inhibits the hyperpolarization of the neuron and reduces the inhibitory effects of GABA. Sr 95531 Hydrobromide′s mechanism of action results in the disinhibition of neuronal activity, leading to increased excitability and potential convulsions. SR 95531 Hydrobromide is used to study the role of GABAA receptors in neuronal signaling and to investigate the mechanisms underlying epilepsy and other neurological disorders.
SR 95531 Hydrobromide (CAS 104104-50-9) References
- Different residues in the GABA(A) receptor alpha 1T60-alpha 1K70 region mediate GABA and SR-95531 actions. | Holden, JH. and Czajkowski, C. 2002. J Biol Chem. 277: 18785-92. PMID: 11896052
- Characterization of antagonistic activity and binding properties of SR 95531, a pyridazinyl-GABA derivative, in rat brain and cultured cerebellar neuronal cells. | Ito, Y., et al. 1992. Synapse. 10: 326-33. PMID: 1585261
- The kinetics of inhibition of rat recombinant heteromeric alpha1beta glycine receptors by the low-affinity antagonist SR-95531. | Beato, M., et al. 2007. J Physiol. 580: 171-9. PMID: 17218350
- Microwave-enhanced synthesis of 2,3,6-trisubstituted pyridazines: application to four-step synthesis of gabazine (SR-95531). | Gavande, N., et al. 2010. Org Biomol Chem. 8: 4131-6. PMID: 20657924
- Synthesis and evaluation of highly potent GABA(A) receptor antagonists based on gabazine (SR-95531). | Iqbal, F., et al. 2011. Bioorg Med Chem Lett. 21: 4252-4. PMID: 21664131
- Effects of GABA antagonists, SR 95531 and bicuculline, on GABAA receptor-regulated chloride flux in rat cortical synaptoneurosomes. | Yu, S. and Ho, IK. 1990. Neurochem Res. 15: 905-10. PMID: 2177155
- The role of GABAA receptor function in peristaltic activity of the guinea-pig ileum: a comparative study with bicuculline, SR 95531 and picrotoxinin. | Tonini, M., et al. 1989. Br J Pharmacol. 97: 556-62. PMID: 2547476
- Partial GABA agonist activity of SR 95531 on the binding of [35S]TBPS, [3H]DMCM and [3H]lormetazepam to rat brain membranes. | Zimmermann, LN., et al. 1989. Biochem Pharmacol. 38: 2889-93. PMID: 2550012
- Binding characteristics reveal partial GABA agonist activities of SR 95531. | Zimmermann, LN., et al. 1989. J Protein Chem. 8: 355-6. PMID: 2551316
- GABA-A Inhibition Shapes the Spatial and Temporal Response Properties of Purkinje Cells in the Macaque Cerebellum. | Blazquez, PM. and Yakusheva, TA. 2015. Cell Rep. 11: 1043-53. PMID: 25959822
- Biochemical characterization of the interaction of three pyridazinyl-GABA derivatives with the GABAA receptor site. | Heaulme, M., et al. 1986. Brain Res. 384: 224-31. PMID: 3022866
- Structural insights into the interaction between gabazine (SR-95531) and Laodelphax striatellus GABA receptors. | Fujie, Y., et al. 2022. J Pestic Sci. 47: 78-85. PMID: 35800394
- GABA antagonists differentiate between recombinant GABAA/benzodiazepine receptor subtypes. | Lüddens, H. and Korpi, ER. 1995. J Neurosci. 15: 6957-62. PMID: 7472452
- The differential antagonism by bicuculline and SR95531 of pentobarbitone-induced currents in cultured hippocampal neurons. | Uchida, I., et al. 1996. Eur J Pharmacol. 307: 89-96. PMID: 8831109
- Contributions of GABAA receptors and GABAC receptors to acetylcholine release and directional selectivity in the rabbit retina. | Massey, SC., et al. 1997. Vis Neurosci. 14: 939-48. PMID: 9364730
Inhibitor of:
GABA Receptor, and GlyR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SR 95531 Hydrobromide, 10 mg | sc-203701 | 10 mg | $205.00 | |||
SR 95531 Hydrobromide, 50 mg | sc-203701A | 50 mg | $720.00 |