Molecular structure of SR 8278, CAS Number: 1254944-66-5
SR 8278 (CAS 1254944-66-5)
Alternate Names:
1,2,3,4-Tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylic Acid Ethyl Ester
CAS Number:
1254944-66-5
Molecular Weight:
361.48
Molecular Formula:
C18H19NO3S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
SR 8278 is a chemical compound that has been studied for its role as a biological modulator. Specifically, it is known as an antagonist of the Rev-Erbα receptor. Rev-Erbα is a nuclear receptor that plays a significant role in regulating circadian rhythm and metabolism. By binding to this receptor, SR 8278 can influence the expression of genes that are controlled by Rev-Erbα. Through its selective binding, SR 8278 offers insights into the modulation of pathways and can be instrumental in the development of novel compounds with optimized properties for research applications.
SR 8278 (CAS 1254944-66-5) References
- Carbon monoxide induces chromatin remodelling to facilitate endothelial cell migration. | Li, M., et al. 2014. Thromb Haemost. 111: 951-9. PMID: 24477332
- The nuclear receptor REV-ERBα regulates Fabp7 and modulates adult hippocampal neurogenesis. | Schnell, A., et al. 2014. PLoS One. 9: e99883. PMID: 24932636
- P19 Cells as a Model for Studying the Circadian Clock in Stem Cells before and after Cell Differentiation. | Mashhour, A., et al. 2018. J Circadian Rhythms. 16: 6. PMID: 30210566
Inhibitor of:
BMAL1, ephrin-A (EFNA), ephrin-A1, Rev-erbα, and Rev-erbβ.Activator of:
SPT6.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SR 8278, 10 mg | sc-473353 | 10 mg | $337.00 |