Molecular structure of SR 59230A hydrochloride, CAS Number: 1135278-41-9
SR 59230A hydrochloride (CAS 1135278-41-9)
See product citations (3)
Application:
SR 59230A hydrochloride is a potent and selective β3 antagonist adrenoceptor
CAS Number:
1135278-41-9
Purity:
≥98%
Molecular Weight:
361.91
Molecular Formula:
C21H27NO2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
SR 59230A hydrochloride is a potent and selective beta3-AR (beta3 adrenoceptor) antagonist (IC50 values are 40, 408 and 648 nM for beta3, beta1 and beta2 receptors respectively). It is also a highly potent, selective and reversible inhibitor of the enzyme phosphodiesterase type 5 (PDE5). This enzyme is responsible for the breakdown of the compound cGMP, which is involved in the regulation of smooth muscle contraction and relaxation. SR 59230A hydrochloride has been studied in cell cultures for its effects on the cardiovascular and endocrine systems, as well as for its potential anti-inflammatory, anti-oxidant, and anticancer properties.
SR 59230A hydrochloride (CAS 1135278-41-9) References
- Stimulation of beta(3)-adrenoceptors causes phosphorylation of p38 mitogen-activated protein kinase via a stimulatory G protein-dependent pathway in 3T3-L1 adipocytes. | Mizuno, K., et al. 2002. Br J Pharmacol. 135: 951-60. PMID: 11861323
- Functional studies of the first selective beta 3-adrenergic receptor antagonist SR 59230A in rat brown adipocytes. | Nisoli, E., et al. 1996. Mol Pharmacol. 49: 7-14. PMID: 8569714
- Functional identification of rat atypical beta-adrenoceptors by the first beta 3-selective antagonists, aryloxypropanolaminotetralins. | Manara, L., et al. 1996. Br J Pharmacol. 117: 435-442. PMID: 8821531
Inhibitor of:
beta1-AR, beta2-AR, and beta3-AR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SR 59230A hydrochloride, 10 mg | sc-204302 | 10 mg | $383.00 | |||
SR 59230A hydrochloride, 50 mg | sc-204302A | 50 mg | $1533.00 |