Molecular structure of SR 58611A, CAS Number: 121524-09-2
SR 58611A (CAS 121524-09-2)
Alternate Names:
Amibegron hydrochloride
Application:
SR 58611A is a selective β3-AR (β3-adrenergic receptor) agonist.
CAS Number:
121524-09-2
Purity:
≥98%
Molecular Weight:
440.36
Molecular Formula:
C22H26ClNO4•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
SR 58611A a membrane permeable compound that has been reported to be a selective β3-AR (β3-adrenergic receptor) agonist.
SR 58611A (CAS 121524-09-2) References
- Sustained improvement in glucose homeostasis in lean and obese mice following chronic administration of the beta 3 agonist SR 58611A. | Williams, CA., et al. 1999. Br J Pharmacol. 128: 1586-92. PMID: 10602340
- Functional assessment of beta adrenoceptor subtypes in human colonic circular and longitudinal (taenia coli) smooth muscle. | Manara, L., et al. 2000. Gut. 47: 337-42. PMID: 10940268
- Effect of SR 58611A, a beta-3 receptor agonist, against experimental gastro-duodenal ulcers. | Vinay, HK., et al. 2002. Indian J Physiol Pharmacol. 46: 36-44. PMID: 12024955
- Evidence against beta 3-adrenoceptors or low affinity state of beta 1-adrenoceptors mediating relaxation in rat isolated aorta. | Brahmadevara, N., et al. 2003. Br J Pharmacol. 138: 99-106. PMID: 12522078
- Beta-adrenoceptor agonist stimulation of acid secretion by rat stomach in vitro is mediated by 'atypical' beta-adrenoceptors. | Canfield, P. and Paraskeva, P. 1992. Br J Pharmacol. 106: 583-6. PMID: 1354542
- Effect of β1 /β2 -adrenoceptor blockade on β3 -adrenoceptor activity in the rat cremaster muscle artery. | Saunders, SL., et al. 2021. Br J Pharmacol. 178: 1789-1804. PMID: 33506492
- Rat frontal cortex beta 1-adrenoceptors are activated by the beta 3-adrenoceptor agonists SR 58611A and SR 58878A but not by BRL 37344 or ICI 215,001. | Nisoli, E., et al. 1995. J Neurochem. 65: 1580-7. PMID: 7561852
- Inhibitory effects of SR 58611A on canine colonic motility: evidence for a role of beta 3-adrenoceptors. | De Ponti, F., et al. 1995. Br J Pharmacol. 114: 1447-53. PMID: 7606348
- Similar atypical beta-adrenergic receptors mediate in vitro rat adipocyte lipolysis and colonic motility inhibition. | Landi, M., et al. 1993. Life Sci. 53: PL297-302. PMID: 7901725
- Effects of two beta 3-adrenoceptor agonists, SR 58611A and BRL 37344, and of salbutamol on cholinergic and NANC neural contraction in guinea-pig main bronchi in vitro. | Martin, CA., et al. 1993. Br J Pharmacol. 110: 1311-6. PMID: 7905768
- Functional evidence for the presence of beta 3-adrenoceptors in the guinea pig common bile duct and colon. | De Ponti, F., et al. 1995. Pharmacology. 51: 288-97. PMID: 8584580
- Functional identification of rat atypical beta-adrenoceptors by the first beta 3-selective antagonists, aryloxypropanolaminotetralins. | Manara, L., et al. 1996. Br J Pharmacol. 117: 435-442. PMID: 8821531
- Effects of beta3-adrenoceptor agonist SR 58611A on gastric acid secretion and histamine release in the dog: comparison with ritodrine. | Bertini, S., et al. 1998. Gen Pharmacol. 31: 625-31. PMID: 9792227
Activator of:
beta3-AR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SR 58611A, 10 mg | sc-361365 | 10 mg | $206.00 | |||
| US: Only available in the US | ||||||
SR 58611A, 50 mg | sc-361365A | 50 mg | $940.00 | |||
| US: Only available in the US | ||||||