Molecular structure of SR 48692, CAS Number: 146362-70-1
SR 48692 (CAS 146362-70-1)
See product citations (2)
Alternate Names:
Meclinertant
Application:
SR 48692 is a neurotensin inhibitor
CAS Number:
146362-70-1
Purity:
≥98%
Molecular Weight:
587.07
Molecular Formula:
C32H31ClN4O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
SR 48692 is a potent and selective non-peptide antagonist of the neurotensin receptor. It binds to the neurotensin receptor with high affinity, inhibiting the binding of neurotensin and preventing its downstream signaling. SR 48692 has been studied for its role in modulating neurotensin-mediated physiological processes. SR 48692 effectively block the effects of neurotensin in various in vitro and in vivo models, making it useful for investigating the physiological and pathological roles of neurotensin signaling.
SR 48692 (CAS 146362-70-1) References
- Pancreatic cancer bears overexpression of neurotensin and neurotensin receptor subtype-1 and SR 48692 counteracts neurotensin induced cell proliferation in human pancreatic ductal carcinoma cell line PANC-1. | Wang, JG., et al. 2011. Neuropeptides. 45: 151-6. PMID: 21272935
- The synthesis of neurotensin antagonist SR 48692 for prostate cancer research. | Baxendale, IR., et al. 2013. Bioorg Med Chem. 21: 4378-87. PMID: 23721919
- Blockade of mast cell histamine secretion in response to neurotensin by SR 48692, a nonpeptide antagonist of the neurotensin brain receptor. | Miller, LA., et al. 1995. Br J Pharmacol. 114: 1466-70. PMID: 7541694
- Differential effects of the nonpeptide neurotensin antagonist, SR 48692, on the pharmacological effects of neurotensin agonists. | Pugsley, TA., et al. 1995. Peptides. 16: 37-44. PMID: 7716073
- Blockade of neurotensin receptor by SR 48692 potentiates the facilitatory effect of haloperidol on the evoked in vivo dopamine release in the rat nucleus accumbens. | Brun, P., et al. 1995. J Neurochem. 64: 2073-9. PMID: 7722490
- Characterization and distribution of binding sites for a new neurotensin receptor antagonist ligand, [3H]SR 48692, in the guinea pig brain. | Betancur, C., et al. 1995. J Pharmacol Exp Ther. 273: 1450-8. PMID: 7791120
- Preexposure to, but not cotreatment with, the neurotensin antagonist SR 48692 delays the development of cocaine sensitization. | Horger, BA., et al. 1994. Neuropsychopharmacology. 11: 215-22. PMID: 7865101
- Effect of the nonpeptide neurotensin antagonist, SR 48692, and two enantiomeric analogs, SR 48527 and SR 49711, on neurotensin binding and contractile responses in guinea pig ileum and colon. | Labbé-Jullié, C., et al. 1994. J Pharmacol Exp Ther. 271: 267-76. PMID: 7965724
- SR 48692, a non-peptide neurotensin receptor antagonist differentially affects neurotensin-induced behaviour and changes in dopaminergic transmission. | Steinberg, R., et al. 1994. Neuroscience. 59: 921-9. PMID: 8058127
- Pharmacological characterization of SR 48692 sensitive neurotensin receptor in human pancreatic cancer cells, MIA PaCa-2. | Yamada, M., et al. 1995. Res Commun Mol Pathol Pharmacol. 90: 37-47. PMID: 8581347
- Antagonism by SR 48692 of mechanical responses to neurotensin in rat intestine. | Mulè, F., et al. 1996. Br J Pharmacol. 117: 488-492. PMID: 8821538
- Negative modulation of nitric oxide production by neurotensin as a putative mechanism of the diuretic action of SR 48692 in rats. | Croci, T., et al. 1997. Br J Pharmacol. 120: 1312-8. PMID: 9105707
- The neurotensin antagonist SR 48692 fails to modify the behavioural responses to a dopamine D1 receptor agonist in the rat. | Stoessl, AJ., et al. 1997. Neuropharmacology. 36: 93-9. PMID: 9144645
- Dose-dependent pain-facilitatory and -inhibitory actions of neurotensin are revealed by SR 48692, a nonpeptide neurotensin antagonist: influence on the antinociceptive effect of morphine. | Smith, DJ., et al. 1997. J Pharmacol Exp Ther. 282: 899-908. PMID: 9262357
- Repeated administration of the neurotensin receptor antagonist SR 48692 differentially regulates mesocortical and mesolimbic dopaminergic systems. | Azzi, M., et al. 1998. J Neurochem. 71: 1158-67. PMID: 9721741
Inhibitor of:
cGKI alpha, CXCR-4, Neurotensin, NHE-9, and secretin receptor.Activator of:
cGKI α, ELL2, FEZ1, and LTB4R2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SR 48692, 5 mg | sc-363290 | 5 mg | $156.00 | |||
SR 48692, 25 mg | sc-363290A | 25 mg | $593.00 | |||
SR 48692, 100 mg | sc-363290B | 100 mg | $2327.00 | |||
SR 48692, 500 mg | sc-363290C | 500 mg | $10500.00 | |||
SR 48692, 1 g | sc-363290D | 1 g | $20990.00 |