Date published: 2026-5-9

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SR 3677 dihydrochloride (CAS 1072959-67-1 (free base))

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Alternate Names:
N-{2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl}-2,3-dihydro-1,4-benzodioxin-2-carboxamide dihydrochloride
Application:
SR 3677 dihydrochloride is a selective and potent Rho-kinase inhibitor
CAS Number:
1072959-67-1 (free base)
Purity:
≥98%
Molecular Weight:
481.37
Molecular Formula:
C22H24N4O42HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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SR 3677 dihydrochloride has emerged as a significant tool in scientific research, particularly in the realm of neuroscience and pharmacology. Its mechanism of action centers around its activity as a selective agonist of the metabotropic glutamate receptor subtype 7 (mGlu7). Through activation of mGlu7 receptors, SR 3677 dihydrochloride modulates synaptic transmission and neuronal excitability in the central nervous system. Research investigations have utilized SR 3677 dihydrochloride to explain the role of mGlu7 receptors in various physiological and pathological conditions, including neurodevelopmental disorders, epilepsy, and mood disorders. Studies have demonstrated its potential in regulating synaptic plasticity, neurotransmitter release, and neuronal network activity, providing insights into the underlying mechanisms of mGlu7 receptor-mediated signaling. Its specificity and efficacy in selectively activating mGlu7 receptors make SR 3677 dihydrochloride a valuable tool for investigating the role of glutamatergic signaling in brain function and dysfunction.


SR 3677 dihydrochloride (CAS 1072959-67-1 (free base)) References

  1. Discovery of substituted 4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors.  |  Feng, Y., et al. 2008. J Med Chem. 51: 6642-5. PMID: 18834107
  2. Rho-kinase mediates diphosphorylation of myosin regulatory light chain in cultured uterine, but not vascular smooth muscle cells.  |  Aguilar, HN., et al. 2012. J Cell Mol Med. 16: 2978-89. PMID: 22947248
  3. Pharmacologic inhibition of ROCK2 suppresses amyloid-β production in an Alzheimer's disease mouse model.  |  Herskowitz, JH., et al. 2013. J Neurosci. 33: 19086-98. PMID: 24305806
  4. ROCK insufficiency attenuates ozone-induced airway hyperresponsiveness in mice.  |  Kasahara, DI., et al. 2015. Am J Physiol Lung Cell Mol Physiol. 309: L736-46. PMID: 26276827
  5. Prognostic value and functional role of ROCK2 in pediatric Ewing sarcoma.  |  Vieira, GM., et al. 2018. Oncol Lett. 15: 2296-2304. PMID: 29434937
  6. Discovery of (S)-6-methoxy-chroman-3-carboxylic acid (4-pyridin-4-yl-phenyl)-amide as potent and isoform selective ROCK2 inhibitors.  |  Pan, J., et al. 2019. Bioorg Med Chem. 27: 1382-1390. PMID: 30819619
  7. Inhibition of Rho-associated kinases suppresses cardiac myofibroblast function in engineered connective and heart muscle tissues.  |  Santos, GL., et al. 2019. J Mol Cell Cardiol. 134: 13-28. PMID: 31233754
  8. Inhibition of ROCK signaling pathway accelerates enteric neural crest cell-based therapy after transplantation in a rat hypoganglionic model.  |  Zhao, Y., et al. 2020. Neurogastroenterol Motil. 32: e13895. PMID: 32515097
  9. Amyloid-β Induces Cdh1-Mediated Rock2 Stabilization Causing Neurodegeneration.  |  Lapresa, R., et al. 2022. Front Pharmacol. 13: 884470. PMID: 35496276
  10. Depletion of Endothelial-Derived 2-AG Reduces Blood-Endothelial Barrier Integrity via Alteration of VE-Cadherin and the Phospho-Proteome.  |  Levine, AA., et al. 2023. Int J Mol Sci. 25: PMID: 38203706

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

SR 3677 dihydrochloride, 10 mg

sc-361364
10 mg
$209.00

SR 3677 dihydrochloride, 50 mg

sc-361364A
50 mg
$906.00