Molecular structure of SR 33805 oxalate, CAS Number: 121346-32-5
SR 33805 oxalate (CAS 121346-32-5)
Application:
SR 33805 oxalate is a potent calcium channel protein inhibitor
CAS Number:
121346-32-5
Molecular Weight:
654.77
Molecular Formula:
C32H40N2O5S.C2H2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SR 33805 oxalate is a potent calcium channel protein inhibitor. SR 33805 oxalate binds allosterically to a1-subunit of L-type Ca2+ channels (Kd = 20 pM), at a site distinct from other types of blocker. SR 33805 oxalate shows some selectivity for vascular smooth muscle, inducing vasorelaxation without producing inotropic or chronotropic effects. SR 33805 oxalate inhibits PDGF-stimulated smooth muscle cell proliferation.
SR 33805 oxalate (CAS 121346-32-5) References
Chatelain et al (1993) In vitro characterization of a novel Ca2+ entry blocker: SR 33805. Eur.J.Pharmacol. 26 181. Romey and Lazdunski (1994) Effects of a new class of calcium antagonists, SR33557 (fantofarone) and SR33805, on neuronal voltage-activated Ca++ channels. J.Pharmacol.Exp.Ther. 271 1348. Magnier-Gaubil et al (1996) Smooth muscle cell cycle and proliferation. Relationship between calcium influx and sarco-endoplasmic reticulum Ca2+ATPase regulation. J.Biol.Chem. 271 27788.Inhibitor of:
Calcium Channel Protein.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SR 33805 oxalate, 10 mg | sc-204299 | 10 mg | $209.00 |