SR-1E Antibody (D-9): sc-390170

SR-1E Antibody (D-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects SR-1E protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SR-1E (D-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SR-1E protein, also known as 5-Hydroxytryptamine Receptor 1E, is a member of the G-protein-coupled receptor family, which plays a crucial role in mediating cellular responses to serotonin, a key neurotransmitter involved in regulating mood, anxiety, and various physiological processes. SR-1E receptor is primarily located in the central nervous system and is involved in inhibitory signaling pathways that modulate neurotransmission. SR-1E receptor′s ability to inhibit adenylyl cyclase activity is significant, as this helps maintain the balance of excitatory and inhibitory signals in the brain, which is essential for proper neuronal function and overall mental health. SR-1E receptor is one of several subtypes within the serotonin receptor family, which includes SR-1A, -1B, -1D, -1E, and -1F, each contributing to the complex signaling mechanisms that underlie various physiological and pathological conditions.

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LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

SR-1E Antibody (D-9) References:

1. Functional expression of the human serotonin 5-HT1A receptor in Escherichia coli. Ligand binding properties and interaction with recombinant G protein alpha-subunits.  |  Bertin, B., et al. 1992. J Biol Chem. 267: 8200-6. PMID: 1533220
2. Molecular cloning of a human gene (S31) encoding a novel serotonin receptor mediating inhibition of adenylyl cyclase.  |  Levy, FO., et al. 1992. FEBS Lett. 296: 201-6. PMID: 1733778
3. Two kinases mediate agonist-dependent phosphorylation and desensitization of the beta 2-adrenergic receptor.  |  Hausdorff, WP., et al. 1990. Symp Soc Exp Biol. 44: 225-40. PMID: 1983369
4. Multiple second messenger pathways of alpha-adrenergic receptor subtypes expressed in eukaryotic cells.  |  Cotecchia, S., et al. 1990. J Biol Chem. 265: 63-9. PMID: 2152928
5. The conserved seven-transmembrane sequence NP(X)2,3Y of the G-protein-coupled receptor superfamily regulates multiple properties of the beta 2-adrenergic receptor.  |  Barak, LS., et al. 1995. Biochemistry. 34: 15407-14. PMID: 7492540
6. Phosphoinositide system-linked serotonin receptor subtypes and their pharmacological properties and clinical correlates.  |  Pandey, SC., et al. 1995. J Psychiatry Neurosci. 20: 215-25. PMID: 7786883

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SR-1E Antibody (D-9) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-SR-1E Antibody (D-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SR-1E Antibody (D-9) Specifications

Alternate Product Name: HTR1E

Product Clone Name: D-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 201-280

Epitope Target: SR-1E

Epitope Species: human

Product Reactivity/Detection: serotonin 1E receptor (5-HT1E)

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for SR-1E Antibody (D-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin