Molecular structure of SR 144528, CAS Number: 192703-06-3
SR 144528 (CAS 192703-06-3)
See product citations (6)
Alternate Names:
5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-[(1R,3S,4S)-2,2,4-trimethyl-3-bicyclo[2.2.1]heptanyl]pyrazole-3-carboxamide
Application:
SR 144528 is a cannabinoid receptor inverse agonist
CAS Number:
192703-06-3
Purity:
≥98%
Molecular Weight:
476.05
Molecular Formula:
C29H34ClN3O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
SR 144528 is a selective peripheral cannabinoid receptor inverse agonist that displays a Ki value of 0.6 nM for rat spleen and human recombinant CB2 receptors and a Ki value of 400 nM for rat brain and human recombinant CB1 receptors.1,2 SR 144528 antagonizes the inhibitory effects of CP 55,940 on forskolin-induced adenylyl cyclase activity in CHO cells expressing hCB2.1 SR 144528 has also been used to investigate the contribution of the CB2 receptor in the control of pain initiation as well as suppression of inflammation and immune activation.3,4,5,6
SR 144528 (CAS 192703-06-3) References
- Mosquitocidal and Anti-Inflammatory Properties of The Essential Oils Obtained from Monoecious, Male, and Female Inflorescences of Hemp (Cannabis sativa L.) and Their Encapsulation in Nanoemulsions. | Rossi, P., et al. 2020. Molecules. 25: PMID: 32751258
- Cannabidiol Improves Random-Pattern Skin Flap Survival in Rats: Involvement of Cannabinoid Type-2 Receptors. | Aryannejad, A., et al. 2023. J Reconstr Microsurg. 39: 48-58. PMID: 35817049
- Design, Synthesis, and Biological Activity of New CB2 Receptor Ligands: from Orthosteric and Allosteric Modulators to Dualsteric/Bitopic Ligands. | Gado, F., et al. 2022. J Med Chem. 65: 9918-9938. PMID: 35849804
- Cannabidiol counters the effects of a dominant-negative pathogenic Kv7.2 variant. | Zhan, X., et al. 2022. iScience. 25: 105092. PMID: 36157585
- Capsaicin Inhibits Multiple Voltage-Gated Ion Channels in Rabbit Ventricular Cardiomyocytes in TRPV1-Independent Manner. | Isaev, D., et al. 2022. Pharmaceuticals (Basel). 15: PMID: 36297299
- Modulatory Activity of the Endocannabinoid System in the Development and Proliferation of Cells in the CNS. | Ruiz-Contreras, HA., et al. 2022. Neurotox Res. 40: 1690-1706. PMID: 36522511
- 2-Arylpropionic Acid Pyrazolamides as Cannabinoid CB2 Receptor Inverse Agonists Endowed with Anti-Inflammatory Properties. | de Oliveira, DR., et al. 2022. Pharmaceuticals (Basel). 15: PMID: 36558970
- Therapeutic Molecular Insights into the Active Engagement of Cannabinoids in the Therapy of Parkinson's Disease: A Novel and Futuristic Approach. | Jain, V., et al. 2023. Neurotox Res. 41: 85-102. PMID: 36567416
- How do phytocannabinoids affect cardiovascular health? An update on the most common cardiovascular diseases. | Dziemitko, S., et al. 2023. Ther Adv Chronic Dis. 14: 20406223221143239. PMID: 36636553
- The Plant Derived 3-3'-Diindolylmethane (DIM) Behaves as CB2 Receptor Agonist in Prostate Cancer Cellular Models. | Tucci, P., et al. 2023. Int J Mol Sci. 24: PMID: 36835033
- Endocannabinoids, anandamide and 2-AG, regulate mechanosensitivity of mucosal afferents in the Guinea pig bladder. | Ramsay, S., et al. 2023. Eur J Pharmacol. 945: 175624. PMID: 36858341
- Library Screening and Preliminary Characterization of Synthetic Cannabinoids Against Prostate and Pancreatic Cancer Cell Lines. | Karelia, D., et al. 2023. Cannabis Cannabinoid Res.. PMID: 36880938
Inhibitor of:
CB2, CBG, CBS, CNR1, CNR2, IP-10, THC, and Vmn2r29.Activator of:
CB2, and CNRIP1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SR 144528, 5 mg | sc-224292 | 5 mg | $282.00 | |||
SR 144528, 10 mg | sc-224292A | 10 mg | $539.00 |