Molecular structure of SR 142948, CAS Number: 184162-64-9
SR 142948 (CAS 184162-64-9)
Application:
SR 142948 is a potent non-peptidic neurotensin receptor inhibitor
CAS Number:
184162-64-9
Molecular Weight:
685.86
Molecular Formula:
C39H51N5O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
Safety Information
SDS & Certificate of Analysis
SR 142948 is a highly potent non-peptide NTR (neurotensin (NT) receptor) antagonist that binds with high affinity (IC50 = 0.32 - 3.96 nM).
SR 142948 (CAS 184162-64-9) References
- In vitro functional evidence of different neurotensin-receptors modulating the motor response of human colonic muscle strips. | Croci, T., et al. 1999. Br J Pharmacol. 127: 1922-8. PMID: 10482925
- Neurotensin reduces glutamatergic transmission in the dorsolateral striatum via retrograde endocannabinoid signaling. | Yin, HH., et al. 2008. Neuropharmacology. 54: 79-86. PMID: 17675102
- Effects of the selective neurotensin antagonist SR 142948A on 3,4-methylenedioxymethamphetamine-induced behaviours in mice. | Marie-Claire, C., et al. 2008. Neuropharmacology. 54: 1107-11. PMID: 18410947
- Neurotensin signaling induces intracellular alkalinization and interleukin-8 expression in human pancreatic cancer cells. | Olszewski, U. and Hamilton, G. 2009. Mol Oncol. 3: 204-13. PMID: 19393580
- Neurotensin co-expressed in orexin-producing neurons in the lateral hypothalamus plays an important role in regulation of sleep/wakefulness states. | Furutani, N., et al. 2013. PLoS One. 8: e62391. PMID: 23620827
- Dependence of Relative Expression of NTR1 and EGFR on Cell Density and Extracellular pH in Human Pancreatic Cancer Cell Lines. | Olszewski-Hamilton, U. and Hamilton, G. 2011. Cancers (Basel). 3: 182-97. PMID: 24212612
- Beneficial Effects of Neurotensin in Murine Model of Hapten-Induced Asthma. | Russjan, E. and Kaczyńska, K. 2019. Int J Mol Sci. 20: PMID: 31614422
- Biochemical and pharmacological activities of SR 142948A, a new potent neurotensin receptor antagonist. | Gully, D., et al. 1997. J Pharmacol Exp Ther. 280: 802-12. PMID: 9023294
- Neurotensin type 1 receptor-mediated activation of krox24, c-fos and Elk-1: preventing effect of the neurotensin antagonists SR 48692 and SR 142948. | Portier, M., et al. 1998. FEBS Lett. 432: 88-93. PMID: 9710257
- X-ray structural characterization of SR 142948, a novel potent synthetic neurotensin receptor antagonist. | Quéré, L., et al. 1998. Bioorg Med Chem Lett. 8: 653-8. PMID: 9871577
Inhibitor of:
Neurotensin, and NTR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SR 142948, 1 mg | sc-204297 | 1 mg | $135.00 | |||
SR 142948, 10 mg | sc-204297A | 10 mg | $286.00 |