Molecular structure of Squalene 2,3:22,23-Dioxide, CAS Number: 31063-19-1
Squalene 2,3:22,23-Dioxide (CAS 31063-19-1)
Alternate Names:
Squalene 2,3:22,23-Dioxide is also known as 2,3:22,23-Dioxidosqualene.
Application:
Squalene 2,3:22,23-Dioxide is a substrate for oxidosqualene cyclase forming 24,25-oxidolanosterol.
CAS Number:
31063-19-1
Molecular Weight:
442.72
Molecular Formula:
C30H50O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Squalene 2,3:22,23-Dioxide is a substrate for oxidosqualene cyclase forming 24,25-oxidolanosterol. In Chinese hamster ovary cells, Squalene 2,3:22,23-Dioxide accumulates during cholesterol biosynthesis inhibition. Squalene 2,3:22,23-dioxide serves as a precursor to sterols and various lipids. It plays a role in the synthesis of carotenoids, which are vital components for photosynthesis in plants.
Squalene 2,3:22,23-Dioxide (CAS 31063-19-1) References
- Induction of CYP3A by 2,3-oxidosqualene:lanosterol cyclase inhibitors is mediated by an endogenous squalene metabolite in primary cultured rat hepatocytes. | Shenoy, SD., et al. 2004. Mol Pharmacol. 65: 1302-12. PMID: 15102959
- Human pregnane X receptor activation and CYP3A4/CYP2B6 induction by 2,3-oxidosqualene:lanosterol cyclase inhibition. | Duniec-Dmuchowski, Z., et al. 2009. Drug Metab Dispos. 37: 900-8. PMID: 19158313
- Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase: search for the enzyme's repressor derived from mevalonate. | Popják, G. and Meenan, A. 1987. Proc R Soc Lond B Biol Sci. 231: 391-414. PMID: 2892200
- Effects of 3 beta-[2-(diethylamino)ethoxy]androst-5-en-17-one on the synthesis of cholesterol and ubiquinone in rat intestinal epithelial cell cultures. | Sexton, RC., et al. 1983. Biochemistry. 22: 5687-92. PMID: 6661410
- Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by oxysterol by-products of cholesterol biosynthesis. Possible mediators of low density lipoprotein action. | Panini, SR., et al. 1984. J Biol Chem. 259: 7767-71. PMID: 6736025
- Inhibition of squalene synthase but not squalene cyclase prevents mevalonate-mediated suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase synthesis at a posttranscriptional level. | Peffley, DM. and Gayen, AK. 1997. Arch Biochem Biophys. 337: 251-60. PMID: 9016820
Inhibitor of:
Squalene epoxidase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Squalene 2,3:22,23-Dioxide, 25 mg | sc-473286 | 25 mg | $306.00 |