Molecular structure of SQ-29548, CAS Number: 98672-91-4
SQ-29548 (CAS 98672-91-4)
See product citations (5)
Alternate Names:
7-[3-[[2-(phenylcarbamoyl)hydrazinyl]methyl]-7-oxabicyclo[2.2.1]heptan-2-yl]hept-5-enoic acid
Application:
SQ-29548 is a potent and selective thromboxane A2 receptor antagonist
CAS Number:
98672-91-4
Purity:
≥98%
Molecular Weight:
387.47
Molecular Formula:
C21H29N3O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
SQ-29548 is a compound that reversibly and competitively acts as a TXA2R (thromboxane A2/prostraglandin endoperoxide receptor) antagonist. Ischemic studies show that SQ 29548 significantly rescues myocardial tissue and Canine postischemic cerebral hypoperfusion studies report that SQ-29548 does not help improve postischemic cerebral hypoperfusion. SQ-29548 may act to bind and inhibit the thromboxane A2/prostaglandin endoperoxide receptor more potently than ONO 3708, BM 13.17, and 13-APA (sc-223165).
SQ-29548 (CAS 98672-91-4) References
- Characterization of the thromboxane receptor mediating prostacyclin release from cultured endothelial cells. | Hunt, JA., et al. 1992. Biochem Pharmacol. 43: 1747-52. PMID: 1315543
- Characterization of thromboxane receptor blocking effects of SQ 29548 in the feline pulmonary vascular bed. | McMahon, TJ., et al. 1992. J Appl Physiol (1985). 72: 1194-200. PMID: 1533211
- Thromboxane A2 receptor antagonist SQ29548 does not improve canine postischemic cerebral hypoperfusion. | Olympio, MA., et al. 1989. J Neurosurg Anesthesiol. 1: 56-62. PMID: 15815240
- Cyclooxygenase and thromboxane/prostaglandin receptor contribute to aortic endothelium-dependent dysfunction in aging female spontaneously hypertensive rats. | Graham, DA. and Rush, JW. 2009. J Appl Physiol (1985). 107: 1059-67. PMID: 19696359
- Involvement of central beta2-adrenergic, NMDA and thromboxane A2 receptors in the pressor effect of anandamide in rats. | Malinowska, B., et al. 2010. Naunyn Schmiedebergs Arch Pharmacol. 381: 349-60. PMID: 20198363
- Simultaneous inhibition of TXA(2) and PGI(2) synthesis increases NO release in mesenteric resistance arteries from cirrhotic rats. | Xavier, FE., et al. 2010. Clin Sci (Lond). 119: 283-92. PMID: 20459396
- Resistance artery mechanics and composition in angiotensin II-infused mice: effects of cyclooxygenase-1 inhibition. | Virdis, A., et al. 2012. Eur Heart J. 33: 2225-34. PMID: 21606076
- Effect of thromboxane A2/endoperoxide antagonist SQ29548 on the contractile response to acetylcholine in newborn piglet cerebral arteries. | Wagerle, LC. and Busija, DW. 1990. Circ Res. 66: 824-31. PMID: 2306808
- Inverse agonism of SQ 29,548 and Ramatroban on Thromboxane A2 receptor. | Chakraborty, R., et al. 2014. PLoS One. 9: e85937. PMID: 24465800
- Brain changes associated with thromboxane receptor antagonist SQ 29,548 treatment in a mouse model. | Rebel, AA., et al. 2015. J Neurosci Res. 93: 1279-92. PMID: 25703023
- Characterization of U46619 binding in unactivated, intact human platelets and determination of binding site affinities of four TXA2/PGH2 receptor antagonists (13-APA, BM 13.177, ONO 3708 and SQ 29,548). | Kattelman, EJ., et al. 1986. Thromb Res. 41: 471-81. PMID: 3008368
- Pharmacological actions of SQ 29,548, a novel selective thromboxane antagonist. | Ogletree, ML., et al. 1985. J Pharmacol Exp Ther. 234: 435-41. PMID: 3926986
- Protective actions of a thromboxane receptor antagonist, SQ 29548 on the ischemic myocardium: morphologic and hemodynamic effects. | Singh, J., et al. 1997. Prostaglandins Leukot Essent Fatty Acids. 56: 105-10. PMID: 9051718
Inhibitor of:
TXA2R.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SQ-29548, 1 mg | sc-201332 | 1 mg | $194.00 | |||
SQ-29548, 10 mg | sc-201332A | 10 mg | $1224.00 |