Molecular structure of Spliceostatin A, CAS Number: 391611-36-2
Spliceostatin A (CAS 391611-36-2)
CAS Number:
391611-36-2
Molecular Weight:
521.64
Molecular Formula:
C28H43NO8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Spliceostatin A (CAS 391611-36-2) References
- Spliceostatin A interaction with SF3B limits U1 snRNP availability and causes premature cleavage and polyadenylation. | Yoshimoto, R., et al. 2021. Cell Chem Biol. 28: 1356-1365.e4. PMID: 33784500
- Spliceostatins and Derivatives: Chemical Syntheses and Biological Properties of Potent Splicing Inhibitors. | Ghosh, AK., et al. 2021. J Nat Prod. 84: 1681-1706. PMID: 33974423
- Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors. | Cretu, C., et al. 2021. Nat Commun. 12: 4491. PMID: 34301950
- CCNE1 and E2F1 Partially Suppress G1 Phase Arrest Caused by Spliceostatin A Treatment. | Kikuchi, K. and Kaida, D. 2021. Int J Mol Sci. 22: PMID: 34769053
- Spliceostatin A stabilizes CDKN1B mRNA through the 3' UTR. | Kaida, D. and Shida, K. 2022. Biochem Biophys Res Commun. 608: 39-44. PMID: 35381427
- Molecular Threat of Splicing Factor Mutations to Myeloid Malignancies and Potential Therapeutic Modulations. | Zhang, F. and Chen, L. 2022. Biomedicines. 10: PMID: 36009519
- Spliceostatin C, a component of a microbial bioherbicide, is a potent phytotoxin that inhibits the spliceosome. | Bajsa-Hirschel, J., et al. 2022. Front Plant Sci. 13: 1019938. PMID: 36714729
- The nexus of long noncoding RNAs, splicing factors, alternative splicing and their modulations. | Malakar, P., et al. 2024. RNA Biol. 21: 1-20. PMID: 38017665
- Small molecule inhibition of RNA binding proteins in haematologic cancer. | Jaiswal, AK., et al. 2024. RNA Biol. 21: 1-14. PMID: 38329136
- A-Z of Epigenetic Readers: Targeting Alternative Splicing and Histone Modification Variants in Cancer. | Mohan, N., et al. 2024. Cancers (Basel). 16: PMID: 38539439
Inhibitor of:
2610027L16Rik, 2810403A07Rik, 82-FIP, 9130206N08Rik, 9G8, BUD13, C16orf33, C16orf57, C19orf29, C1orf114, Caper, CASC3, CAT56, Cdc40, Cdc5L, CELF6, CNOT10, CPSF6, CTA, CWC15, CWC22, DDX23, DDX25, DDX28, DDX30, DDX39, DDX40, DIS3L, E130309D02Rik, Edc3, Edc4, EXOSC (exosome component), EXOSC2, EXOSC3, EXOSC5, FUSIP1, GPATCH2, GPATCH8, GRSF-1, GSE1, HARE, HEAB, hnRNP A/B, hnRNP A3, hnRNP H′/hnRNP H2, hnRNP J, hnRNP L, hnRNP Q, hnRNP UL1, HPS-3, INTS3, INTS4, IQCF2, Kaptin, KIAA0649, Krtap31-2, LARP5, LIPI, LSm4, LSm7, Mex3a, MRT4, NOL11, Nop14, Nova-2, NPWBP, NYNRIN, Pcf11, PNLDC1, PRKRIP1, PRP19, PRP4 kinase, PRP6, PRP8, PRPF18, PRPF3, PRPF31, PRPF38B, PRPF40B, Pumilio 2, RBM12, RBM12B, RBM15, RBM16, RBM18, RBM20, RBM22, RBM25, RBM34, RBM4, RBM41, RBM7, RBMS2, RBMXL2, RBMY1E, RNPC3, RNPS1, RP11-430L17.1, RP11-592B15.4, Rpp30, RSL24D1, Sab, SAP 14_SF3B14, SAP 155, SAP 49, SAP 62, SART-1, SC35, SDCCAG10, SF3B10, SF3B3, SFRS11, SFRS12, SFRS12IP1, SFRS14, SFRS15, SFRS16, SFRS2IP, SFRS8, Six6os1, Ski2, Sm D2, Sm G, SmB, SMG5, SMU1, SNRNP48, SNRPA, SNRPC, SON, SRE-ZBP, SRm300_Srrm2, SRp20, SRp30a, SRp30b, SRp30c, SRRM3, SRrp35, STAU1, TFIID, TFIIIC90, TOE1, Tom23, Tra-2α, TRAP100, TRAP150, TSEN54, U11, U11/U12 snRNP 20K, U11/U12 snRNP 25, U2 snRNP A, U2 snRNP B, U2AF1L3, U2AF35, USH1G, USP39, WBSCR27, WDR43, WDR70, Y14_RBM8, ZC3H14, ZCCHC11, ZCCHC4, ZCCHC8, ZFR2, ZNF265, ZNF425, ZNF768, ZRSR1, and ZRSR2.Activator of:
AQR, BRUNOL4, BZW1, C20orf78, CBP80, CstF-50, DDX1, DDX28, DDX36, DOM3Z, EAP1, EIF3S6IP, Gemin6, GPATCH4, hnRNP A3, hnRNP H3, HNRNPA1L2, LARP2, LSm11, LSm5, LTV1, MFAP1A, Nop56, Nova-1, PHF5A, PNPase, Pol III RPC39, PRPF4, PTBP-2, PUS4_TRUB1, RBM23, RBM33, RBM35A, RBM9, RBMXL3, RBP-L, RBPMS2, Rent2, RNase 2, RSRC2, SAP 155, SF4, SFRS17A, SLBP, SLU7, Sm E, SMG8, SR140, SRm160, SRp55, SYF2, U11/U12 snRNP 25, U2 snRNP B, U2 snRNP B′′, WDR12, WDR4, and ZGPAT.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Spliceostatin A, 1 mg | sc-507481 | 1 mg | $1800.00 |