Molecular structure of sPLA2 inhibitor, CAS Number: 393569-31-8
sPLA2 inhibitor Inhibitor (CAS 393569-31-8)
Application:
sPLA2 inhibitor is an inhibitor of phospholipase A2
CAS Number:
393569-31-8
Molecular Weight:
487.63
Molecular Formula:
C31H37NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Orally active, potent secretory Phospholipase A2 (sPLA2; Group IIa) inhibitor.
sPLA2 inhibitor Inhibitor (CAS 393569-31-8) References
- Suppression of murine endotoxic shock by sPLA2 inhibitor, indoxam, through group IIA sPLA2-independent mechanisms. | Yokota, Y., et al. 1999. Biochim Biophys Acta. 1438: 213-22. PMID: 10320804
- Comparative protection against rat intestinal reperfusion injury by a new inhibitor of sPLA2, COX-1 and COX-2 selective inhibitors, and an LTC4 receptor antagonist. | Arumugam, TV., et al. 2003. Br J Pharmacol. 140: 71-80. PMID: 12967936
- Inhibitors of secretory phospholipase A2 group IIA. | Reid, RC. 2005. Curr Med Chem. 12: 3011-26. PMID: 16378502
- Antifibrotic activity of an inhibitor of group IIA secretory phospholipase A2 in young spontaneously hypertensive rats. | Levick, S., et al. 2006. J Immunol. 176: 7000-7. PMID: 16709861
- MMP production in human fibrosarcoma cells and their invasiveness are regulated by group IB secretory phospholipase A2 receptor-mediated activation of cytosolic phospholipase A2. | Gorovetz, M., et al. 2008. Front Biosci. 13: 1917-25. PMID: 17981679
- Differential expression of sPLA2 following spinal cord injury and a functional role for sPLA2-IIA in mediating oligodendrocyte death. | Titsworth, WL., et al. 2009. Glia. 57: 1521-37. PMID: 19306380
- An inhibitor of phospholipase A2 group IIA modulates adipocyte signaling and protects against diet-induced metabolic syndrome in rats. | Iyer, A., et al. 2012. Diabetes. 61: 2320-9. PMID: 22923652
- Group IIa sPLA2 inhibition attenuates NF-κB activity and promotes apoptosis of lung cancer cells. | Yu, JA., et al. 2012. Anticancer Res. 32: 3601-7. PMID: 22993297
- Group IIa secretory phospholipase expression correlates with group IIa secretory phospholipase inhibition-mediated cell death in K-ras mutant lung cancer cells. | Yu, JA., et al. 2012. J Thorac Cardiovasc Surg. 144: 1479-85. PMID: 23026567
- sPLA2-IIA Augments Oxidized LDL-Induced MCP-1 Expression in Vitro Through Activation of Akt. | Guo, Y., et al. 2015. Cell Physiol Biochem. 37: 1345-54. PMID: 26488172
Inhibitor of:
group II sPLA2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
sPLA2 inhibitor, 5 mg | sc-215901 | 5 mg | $275.00 | |||
sPLA2 inhibitor, 25 mg | sc-215901A | 25 mg | $1009.00 |