Molecular structure of Spiroxatrine (R 5188), CAS Number: 1054-88-2
Spiroxatrine (R 5188) (CAS 1054-88-2)
Application:
Spiroxatrine (R 5188) is a SR-1A antagonist
CAS Number:
1054-88-2
Molecular Weight:
379.46
Molecular Formula:
C22H25N3O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Spiroxatrine (R 5188) is a serotonin 5-HT1A antagonist1.
Spiroxatrine (R 5188) (CAS 1054-88-2) References
- Alpha 1-adrenoceptor blocking properties of spiroxatrine in rat aorta. | Terrón, JA., et al. 1992. Life Sci. 51: PL1-6. PMID: 1352025
- Involvement of the first transmembrane segment of human α(2) -adrenoceptors in the subtype-selective binding of chlorpromazine, spiperone and spiroxatrine. | Laurila, JM., et al. 2011. Br J Pharmacol. 164: 1558-72. PMID: 21649638
- Behavioral and neurochemical effects of the serotonin (5-HT)1A receptor ligand spiroxatrine. | Barrett, JE., et al. 1989. Psychopharmacology (Berl). 97: 319-25. PMID: 2524083
- Spiroxatrine augments fluoxetine-induced reduction of ethanol intake by the P line of rats. | McBride, WJ., et al. 1989. Pharmacol Biochem Behav. 34: 381-6. PMID: 2533688
- Involvement of brain 5-HT1A receptors in the hypotensive response to urapidil. | Kolassa, N., et al. 1989. Am J Cardiol. 64: 7D-10D. PMID: 2569265
- The effects of progesterone on the alpha2-adrenergic receptor subtypes in late-pregnant uterine contractions in vitro. | Hajagos-Tóth, J., et al. 2016. Reprod Biol Endocrinol. 14: 33. PMID: 27301276
- Serotonergic properties of spiroxatrine enantiomers. | Nikam, SS., et al. 1988. J Med Chem. 31: 1965-8. PMID: 2902227
- [3H]spiroxatrine labels a serotonin1A-like site in the rat hippocampus. | Nelson, DL., et al. 1987. Life Sci. 41: 1567-76. PMID: 2957559
- [3H]spiroxatrine: a 5-HT1A radioligand with agonist binding properties. | Herrick-Davis, K. and Titeler, M. 1988. J Neurochem. 50: 528-33. PMID: 2961850
- Dopamine antagonistic effects of a series of analogues of oxiperomide and spiroxatrine measured behaviourally in the rodent. | Costall, B. and Naylor, RJ. 1978. J Pharm Pharmacol. 30: 693-8. PMID: 31432
- Spiroxatrine derivatives towards 5-HT1A receptor selectivity. | Sorbi, C., et al. 2020. Pharmacol Rep. 72: 427-434. PMID: 32002826
- Centrally acting hypotensive agents with affinity for 5-HT1A binding sites inhibit forskolin-stimulated adenylate cyclase activity in calf hippocampus. | Schoeffter, P. and Hoyer, D. 1988. Br J Pharmacol. 95: 975-85. PMID: 3207999
- Spiroxatrine: a selective serotonin1A receptor antagonist. | Nelson, DL. and Taylor, EW. 1986. Eur J Pharmacol. 124: 207-8. PMID: 3720840
Inhibitor of:
alpha2C-AR, and SR-1A.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Spiroxatrine (R 5188), 10 mg | sc-201148 | 10 mg | $130.00 |