Spiramycin III (CAS 24916-52-7)
Alternate Names:
Spiramycin C
CAS Number:
24916-52-7
Molecular Weight:
899.12
Molecular Formula:
C46H78N2O15
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Spiramycin III is an antibiotic chemical within the erythromycin/carbomycin group of compounds. It inhibits the binding of tetrahydroleucomycin A3 to E. coli ribosomes (IC50 = 1 µM) and is active against S. aureus, B. subtilis, B. cereus, and M. luteus (MICs = 3.12, 1.56, 3.12, and 0.1 µg/ml, respectively). Spiramycin III protects mice from S. aureus, S. pneumoniae, and P. berghei infections (ED50s = 116.6, 167.9, and 27 mg/kg, respectively).
Spiramycin III (CAS 24916-52-7) References
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- Separation of spiramycin components using high-speed counter-current chromatography. | Oka, H., et al. 2000. J Chromatogr A. 903: 93-8. PMID: 11153959
- Identification and quantification method of spiramycin and tylosin in feedingstuffs with HPLC-UV/DAD at 1 ppm level. | Civitareale, C., et al. 2004. J Pharm Biomed Anal. 36: 317-25. PMID: 15496324
- Effect of leucomycins and analogues on binding [14C ]erythromycin to Escherichia coli ribosomes. | Pestka, S., et al. 1974. Antimicrob Agents Chemother. 6: 606-12. PMID: 15825314
- Organization of the biosynthetic gene cluster for the macrolide antibiotic spiramycin in Streptomyces ambofaciens. | Karray, F., et al. 2007. Microbiology (Reading). 153: 4111-4122. PMID: 18048924
- Hydroxylation and hydrolysis: two main metabolic ways of spiramycin I in anaerobic digestion. | Zhu, P., et al. 2014. Bioresour Technol. 153: 95-100. PMID: 24345568
- Identification of 4″-isovaleryl-spiramycin III produced by Bacillus sp. fmbJ. | Deng, Y., et al. 2014. Arch Microbiol. 196: 87-95. PMID: 24356910
- Influence of Al3+ on the titer of spiramycin and effective components in fermentor. | Li, Z., et al. 2017. Prep Biochem Biotechnol. 47: 481-488. PMID: 28278108
- Challenges for the determination of spiramycin in aqueous matrices using LC-MS/MS: evidence for the solvent intrusion on the molecule integrity. | Nasiri, A., et al. 2022. RSC Adv. 12: 17096-17103. PMID: 35755590
- Antibiotics as probes of ribosome structure: binding of chloramphenicol and erythromycin to polyribosomes; effect of other antibiotics. | Pestka, S. 1974. Antimicrob Agents Chemother. 5: 255-67. PMID: 4599122
- Inhibitors of protein synthesis at the ribosome level. Studies on their site of action. | Vazquez, D. 1967. Life Sci. 6: 381-6. PMID: 5340250
- Pharmacokinetics of spiramycin in the rhesus monkey: transplacental passage and distribution in tissue in the fetus. | Schoondermark-Van de Ven, E., et al. 1994. Antimicrob Agents Chemother. 38: 1922-9. PMID: 7810999
- Study of the metabolism of spiramycin in pig liver. | Mourier, P. and Brun, A. 1997. J Chromatogr B Biomed Sci Appl. 704: 197-205. PMID: 9518151
- Development of Validated Chromatographic Methods for the Simultaneous Determination of Metronidazole and Spiramycin in Tablets | Hadir M. Maher & Rasha M. Youssef. 2009. Chromatographia. 69: 345–350.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Spiramycin III, 50 mg | sc-474405 | 50 mg | $311.00 |