Molecular structure of SPHK 1 Inhibitor 5C, CAS Number: 120005-55-2
SPHK 1 Inhibitor 5C (CAS 120005-55-2)
See product citations (5)
Alternate Names:
SKI 5C; CAY10621
Application:
SPHK 1 Inhibitor 5C is a selective inhibitor of SphK1
CAS Number:
120005-55-2
Purity:
≥98%
Molecular Weight:
435.64
Molecular Formula:
C26H45NO4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
SPHK 1 Inhibitor 5C is a selective inhibitor of SphK1, both in vitro (IC50 = 3.3 muM) and in U937 cells overexpressing human SphK1 (70% inhibition at 5 muM). The sphingosine kinases (SphK) phosphorylate sphingosine, producing the important lipid mediator sphingosine-1-phosphate (S1P). The two known kinases, SphK1 and SphK2, have different developmental and tissue expression patterns, suggesting that they have distinct physiological functions. Notably, SphK1 is overexpressed in several forms of cancer and inhibition of SphK1 inhibits tumor growth. It has no inhibitory effect on SphK2 either in vitro or in cells. Similarly, this chemical does not reduce the activity of protein kinase C (PKC) except at very high concentration (>75 muM).
SPHK 1 Inhibitor 5C (CAS 120005-55-2) References
- Functions of the multifaceted family of sphingosine kinases and some close relatives. | Spiegel, S. and Milstien, S. 2007. J Biol Chem. 282: 2125-9. PMID: 17135245
- 'Inside-out' signaling of sphingosine-1-phosphate: therapeutic targets. | Takabe, K., et al. 2008. Pharmacol Rev. 60: 181-95. PMID: 18552276
- Targeting SphK1 as a new strategy against cancer. | Shida, D., et al. 2008. Curr Drug Targets. 9: 662-73. PMID: 18691013
- Synthesis and evaluation of sphingosine analogues as inhibitors of sphingosine kinases. | Wong, L., et al. 2009. J Med Chem. 52: 3618-26. PMID: 19469544
- Sphingosine kinase 1 promotes tumour cell migration and invasion via the S1P/EDG1 axis in hepatocellular carcinoma. | Bao, M., et al. 2012. Liver Int. 32: 331-8. PMID: 22098666
- Sphingosine kinase 1 promotes malignant progression in colon cancer and independently predicts survival of patients with colon cancer by competing risk approach in South asian population. | Tan, SS., et al. 2014. Clin Transl Gastroenterol. 5: e51. PMID: 24572701
- SPHK1 regulates proliferation and survival responses in triple-negative breast cancer. | Datta, A., et al. 2014. Oncotarget. 5: 5920-33. PMID: 25153718
- Sphingosine kinase 1 mediates neuroinflammation following cerebral ischemia. | Zheng, S., et al. 2015. Exp Neurol. 272: 160-9. PMID: 25797575
- Sphingosine-1-phosphate is involved in inflammatory reactions in patients with Graves' orbitopathy. | Seo, Y., et al. 2017. Inflamm Res. 66: 535-545. PMID: 28364200
- Sphingosine Kinase 1 Regulates Inflammation and Contributes to Acute Lung Injury in Pneumococcal Pneumonia via the Sphingosine-1-Phosphate Receptor 2. | Gutbier, B., et al. 2018. Crit Care Med. 46: e258-e267. PMID: 29298188
- Transforming Growth Factor β1 (TGF-β1) Appears to Promote Coronary Artery Disease by Upregulating Sphingosine Kinase 1 (SPHK1) and Further Upregulating Its Downstream TIMP-1. | Wang, S., et al. 2018. Med Sci Monit. 24: 7322-7328. PMID: 30317247
- LncRNA HULC promotes non-small cell lung cancer cell proliferation and inhibits the apoptosis by up-regulating sphingosine kinase 1 (SPHK1) and its downstream PI3K/Akt pathway. | Liu, L., et al. 2018. Eur Rev Med Pharmacol Sci. 22: 8722-8730. PMID: 30575912
- Identifying novel sphingosine kinase 1 inhibitors as therapeutics against breast cancer. | Khan, FI., et al. 2020. J Enzyme Inhib Med Chem. 35: 172-186. PMID: 31752564
- Hemorrhage-Induced Sphingosine Kinase 1 Contributes to Ferroptosis-Mediated Secondary Brain Injury in Intracerebral Hemorrhage. | Diao, X., et al. 2022. Mol Neurobiol. 59: 1381-1397. PMID: 34993846
- Kaempferol alleviates the inflammatory response and stabilizes the pulmonary vascular endothelial barrier in LPS-induced sepsis through regulating the SphK1/S1P signaling pathway. | Zhu, X., et al. 2022. Chem Biol Interact. 368: 110221. PMID: 36243145
Inhibitor of:
SphK1, and SphK2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SPHK 1 Inhibitor 5C, 1 mg | sc-288340 | 1 mg | $57.00 | |||
SPHK 1 Inhibitor 5C, 5 mg | sc-288340A | 5 mg | $158.00 |