Spermine, Tetrahydrochloride CAS: 306-67-2
MF: C10H26N4•4HCl
MW: 348.3
An inhibitor of NOS1, NMDA, GluR, and PLCα.

Spermine, Tetrahydrochloride (CAS 306-67-2)

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Synonym: N,N'-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride
Application: An inhibitor of NOS1, NMDA, GluR, and PLCα
CAS Number: 306-67-2
Molecular Weight: 348.3
Molecular Formula: C10H26N44HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Spermine is a biogenic polyamine formed from spermidine (sc-215900) and occurs in almost all tissues. It is essential for both neoplastic and normal tissue growth and is involved in the modulation of calcium-dependent immune processes. Spermine inhibits NOS1 (nNOS). Spermine binds to and activates or inhibits NMDA depending on the subunit composition of the receptor. Spermine is a GluR inhibitor. Spermine is an inhibitor of PLCα and activator of PLCδ.


1. Pawelczyk, T., et al. 1992. Arch. Biochem. Biophys. 297: 328-333. PMID: 1497353
2. Khan, A.U., et al. 1992. Proc. Natl. Acad. Sci. U.S.A. 89: 11428-11430. PMID: 1454831
3. Escargueil-Blanc, I., et al. 1994. FASEB J. 8: 1075-1080. PMID: 7926374
4. Hu, J., et al. 1994. Neurosci. Lett. 175: 41-45. PMID: 7526294
5. Igarashi, K., et al. 1995. J. Pharmacol. Exp. Ther. 272: 1101-1109. PMID: 7891322

Physical State :
Solubility :
Soluble in water (348.2 g/l at 20° C).
Storage :
Store at room temperature
Melting Point :
310-311° C (lit.)(dec.)
Boiling Point :
308.4° C at 760 mmHg (Predicted)
Refractive Index :
n20D 1.49 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
PubChem CID :
Merck Index :
14: 8743
MDL Number :
EC Number :
Beilstein Registry :

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Certificate of Analysis

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