Molecular structure of Spermine diphosphate hydrate, CAS Number: 3891-79-0
Spermine diphosphate hydrate (CAS 3891-79-0)
Application:
Spermine diphosphate hydrate is a mixed NMDA agonist/antagonist
CAS Number:
3891-79-0
Molecular Weight:
398.33
Molecular Formula:
C10H26N4•2H3PO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Mixed NMDA agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS). It enhances agonist effectiveness at the strychnine-insensitive glycine site.
Spermine diphosphate hydrate (CAS 3891-79-0) References
Sharma, T.A., and Reynolds, I.J., Characterization of the effects of polyamines on [125I]MK-801 binding to recombinant N-methyl-D-aspartate receptors. J. Pharmacol. Exp. Ther. 289, 1041-1047, (1999) Ferchmin, P.A., et al., Spermine is neuroprotective against anoxia and N-methyl-D-aspartate in hippocampal slices. Brain Res. 859, 273-279, (2000) Sacaan, A.I., and Johnson, K.M., Spermine enhances binding to the glycine site associated with the N-methyl-D-aspartate receptor complex. Mol. Pharmacol. 36, 836-839, (1989) Hu, J., et al., Polyamines inhibit nitric oxide synthase in rat cerebellum. Neurosci. Lett. 175, 41-45, (1994)Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Spermine diphosphate hydrate, 1 g | sc-253603 | 1 g | $208.00 |