Molecular structure of Spermine dihydrate
Spermine dihydrate (CAS 403982-64-9)
Alternate Names:
Gerontine; (N,N)-1,4-butanediamine dihydrate
Application:
Spermine dihydrate is a polyamine used in proteomics reseach
CAS Number:
403982-64-9
Molecular Weight:
238.37
Molecular Formula:
C10H26N4•2H2O
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Spermine dihydrate, also known as SPM-2H2O, is a naturally occurring small molecule that is widely present in organisms including humans. Derived from the amino acid arginine, it serves as a vital constituent of cell membranes. Additionally, spermine dihydrate finds use as a fluorescent probe for imaging purposes and as a stabilizing agent for proteins. Spermine dihydrate is believed to function as a chelating agent, binding to essential metal ions such as calcium, magnesium, and iron. This binding activity plays a role in stabilizing proteins and other molecules within the cell membrane. Furthermore, spermine dihydrate engages in interactions with other molecules like lipids and proteins.
Spermine dihydrate (CAS 403982-64-9) References
- Development of glutamatergic synaptic transmission in binaural auditory neurons. | Sanchez, JT., et al. 2010. J Neurophysiol. 104: 1774-89. PMID: 20668278
- Transgenic quail as a model for research in the avian nervous system: a comparative study of the auditory brainstem. | Seidl, AH., et al. 2013. J Comp Neurol. 521: 5-23. PMID: 22806400
- Downregulation of Spermine Augments Dendritic Persistent Sodium Currents and Synaptic Integration after Status Epilepticus. | Royeck, M., et al. 2015. J Neurosci. 35: 15240-53. PMID: 26586813
- The Vibrio cholerae SpeG Spermidine/Spermine N-Acetyltransferase Allosteric Loop and β6-β7 Structural Elements Are Critical for Kinetic Activity. | Le, VTB., et al. 2021. Front Mol Biosci. 8: 645768. PMID: 33928120
- Common synaptic phenotypes arising from diverse mutations in the human NMDA receptor subunit GluN2A. | Elmasri, M., et al. 2022. Commun Biol. 5: 174. PMID: 35228668
- Synaptic Dysfunction by Mutations in GRIN2B: Influence of Triheteromeric NMDA Receptors on Gain-of-Function and Loss-of-Function Mutant Classification. | Elmasri, M., et al. 2022. Brain Sci. 12: PMID: 35741674
- Structure of human spermine oxidase in complex with a highly selective allosteric inhibitor. | Diaz, E., et al. 2022. Commun Biol. 5: 787. PMID: 35931745
Activator of:
Ribosomal Protein L18.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Spermine dihydrate, 1 g | sc-470016 | 1 g | $65.00 | |||
Spermine dihydrate, 5 g | sc-470016A | 5 g | $292.00 |