Spermine-butane-d8 tetrahydrochloride (CAS 1173022-85-9)

Spermine-butane-d8 tetrahydrochloride is a chemically labeled variant of spermine, extensively utilized in biochemical and molecular biology research due to its incorporation of deuterium atoms, which are heavier isotopes of hydrogen. This modification significantly enhances the molecule′s utility in nuclear magnetic resonance (NMR) spectroscopy studies, providing clearer insights into molecular dynamics and interactions due to the distinct signal properties of deuterium. This compound plays a pivotal role in probing the conformational changes and binding behaviors of nucleic acids, particularly DNA and RNA, where spermine naturally interacts through electrostatic forces to stabilize their structures. The addition of the tetrahydrochloride salt enhances the solubility and handling characteristics of the molecule, making it highly suitable for experiments that require precise control of biochemical conditions. The application of spermine-butane-d8 tetrahydrochloride in research thus contributes profoundly to our understanding of the molecular mechanisms underlying nucleic acid function and regulation.