Molecular structure of Spermine, CAS Number: 71-44-3
Spermine (CAS 71-44-3)
See product citations (1)
Alternate Names:
Musculamine; Neuridine
Application:
Spermine is a NOS1 inhibitor, NMDA activator, and GluR inhibitor
CAS Number:
71-44-3
Purity:
≥98%
Molecular Weight:
202.34
Molecular Formula:
C10H26N4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Spermine is a biogenic polyamine formed from spermidine (sc-215900) and occurs in almost all tissues. It is essential for both neoplastic and normal tissue growth and is involved in the modulation of calcium-dependent immune processes. Spermine inhibits NOS1 (nNOS). Spermine binds to and activates NMDA and may act to potentiate NMDA-induced currents in a concentration-dependent manner. Spermine is a GluR inhibitor.
Spermine (CAS 71-44-3) References
- Spermine is neuroprotective against anoxia and N-methyl-D-aspartate in hippocampal slices. | Ferchmin, PA., et al. 2000. Brain Res. 859: 273-9. PMID: 10719074
- Spermine cytotoxicity to human colon carcinoma-derived cells (CaCo-2). | Seiler, N., et al. 2000. Cell Biol Toxicol. 16: 117-30. PMID: 10917567
- Spermine ameliorates ischemia/reperfusion injury in cardiomyocytes via regulation of autophagy. | Duan, Q., et al. 2016. Am J Transl Res. 8: 3976-3985. PMID: 27725878
- Detection of Thermospermine and Spermine by HPLC in Plants. | Takahashi, T., et al. 2018. Methods Mol Biol. 1694: 69-73. PMID: 29080156
- Spermine and spermidine are cytotoxic towards intestinal cell cultures, but are they a health hazard at concentrations found in foods? | Del Rio, B., et al. 2018. Food Chem. 269: 321-326. PMID: 30100441
- Spermine and oxacillin stress response on the cell wall synthesis and the global gene expression analysis in Methicillin-resistance Staphylococcus aureus. | Pawar, S., et al. 2019. Genes Genomics. 41: 43-59. PMID: 30229508
- Spermine as a porcine pancreatic elastase activator: spectroscopic and molecular simulation studies. | Sadeghi-Kaji, S., et al. 2020. J Biomol Struct Dyn. 38: 78-88. PMID: 30810494
- Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice. | Xu, TT., et al. 2020. Aging (Albany NY). 12: 6401-6414. PMID: 32268299
- Exploring the structural basis of conformational alterations of myoglobin in the presence of spermine through computational modeling, molecular dynamics simulations, and spectroscopy methods. | Eslami-Farsani, R., et al. 2022. J Biomol Struct Dyn. 40: 3581-3594. PMID: 33308044
- Effects of spermine on the proliferation and migration of porcine intestinal epithelial cells. | Xu, X., et al. 2021. Anim Biotechnol. 1-8. PMID: 34369303
- Spermine protects intestinal barrier integrity through ras-related C3 botulinum toxin substrate 1/phospholipase C-γ1 signaling pathway in piglets. | Liu, G., et al. 2022. Anim Nutr. 8: 135-143. PMID: 34977383
- Spermine inhibits PAMP-induced ROS and Ca2+ burst and reshapes the transcriptional landscape of PAMP-triggered immunity in Arabidopsis. | Zhang, C., et al. 2023. J Exp Bot. 74: 427-442. PMID: 36264272
- Elevation of spermine remodels immunosuppressive microenvironment through driving the modification of PD-L1 in hepatocellular carcinoma. | Shi, HX., et al. 2022. Cell Commun Signal. 20: 175. PMID: 36348350
Inhibitor of:
Agmatinase, CCDC109A, GluR, LTRPC7, NOS1, OAZIN, PMFBP1, putrescine extracellular binding protein, STOML2, TMEM63B, VDAC1, and ZNF364.Activator of:
1110014J01Rik, 1600012H06Rik, 1700009C05Rik, 1700009N14Rik, 1700013G24Rik, 1810065E05Rik, 2010007H12Rik, 2410076I21Rik, 2610003J06Rik, 2610034B18Rik, 26S Proteasome p58, 2700062C07Rik, 2810002N01Rik, 4930412D23Rik, 4930422G04Rik, 4930503L19Rik, 4930564B18Rik, 4930578C19Rik, 4931408C20Rik, 5930416I19Rik, 6030422M02Rik, 6530403A03Rik, A230107C01Rik, Abp β, ADAM22, Aftiphilin, AI462493, Amd2, AMDHD1, AMIGO3, ANKRD21, ANKRD22, ANKRD37, ANKRD44, ANKRD7, AQP1, ARMS, ARP, Arylsulfatase B, Astrotactin, Astrotactin 2, ATHL1, AU042671, B930011P16Rik, BC021614, BC026374, BC049762, BIN2, BLCAP, BLU, BTBD17, C. trachomatis MOMP, C11orf42, C14orf79, C15orf58, C17orf75, C19orf52, C1orf190, C2orf37, C5orf34_4833420G17Rik, C5orf46, C5orf49_1700001L19Rik, C6orf125, C6orf128, C6orf132, C6orf141, C6orf145, C7orf26, C8α, C8orf31, C9orf30, C9orf47, C9orf71, C9orf97, CaMK1γ, CapZ-α1, casein kinase IIβ, CaT1, CCDC173, CCDC7, CCDC74B, CCT8L1, CD23, COL4A6, CPS II, CREG2, CstF-77, CWF19L2, CXorf66, DAP-5, DDTL, Digoxigenin, DNHD2, DNLZ, dNT-2, DNTNP, DNTTIP2, Doc 4, Dok-7, DPEP2, E430029J22Rik, Ear1, EG635895, EG667705, EG668359, EG668379, ENY2, EPSTI1, Esp3, Esp34, Etohi1, Exo1, F8A1, F8A3, FAHD2B, FAM12B, FAM158A, FAM169A, FAM180B, FAM188B, FAM21B, FAM22F, FAM24A, FAM25A, FAM69B, FAM75A1, FAM75A6, FAM75C2, FAM83G, FBL3B, FBXO34, FER1L6, FLJ10489, FLJ37396, FLJ46321, FOXD4L1-6, FOXD4L5, GADD 45, Gas7, GIOT-1, GLP-2R, Gm447, Gm97, GMEB-2, GRIN2, GS27, GTL3, Gtlf3b, HIPK4_Hipk4, hippocalcin, Homer-3, IGF-IIR, IL-10, IL-20Rβ, Irgm2, JTB, KIAA0226, KIAA1267, KIAA1377, KIAA1407, KIAA1751, KIAA1958, KIR2.1, KIR2.3, KIR5.1, KLHL8, KLRG2, LCHN_E330009J07Rik, LOC100039596, LOC388553, LRP16, LRRC33, LRRC47, LRRC61, LRRN2, LTRPC7, LYPD4, MAMDC2, MAST1, MAST3, mCST E2, MCT8, MGC42105, MKP-5, MMGT1, Morc, MTMR14, N-SMase2, NAALAD2, NAALADL1, NALP4A, NAT-15, NAT-3, NDUFA11, NDUFB7, NHE-6, NIPSNAP3B, nm23-H2, NMDA, NMDAε3, NMDAε4, NMDAζ1, NR3A, NR3B, NYD-SP15, OAZ, ODCp, Odf3l2, Odin, OR13C5, OR13D1, OR4C16, OTTMUSG00000017976, OTTMUSG00000018258, PAOX, PATE2, PATZ1, PDC-TREM, PDZK7, Pet2, Pi15, Pilr-β2, Pira1, Pira2, Pira4, Placental lactogen Iβ, PLP-A, PLP-Cα, PLP-Cγ, PLP-E, PLP-H, PP2Cα, PP2Cγ, PPP1R1C, PSD, PTPσ, PTPN21, putrescine extracellular binding protein, rabphilin-3A, RBM22, Reg Iβ, REP-2, Retnlb, Rhox8, RHOXF2B, Riboflavin kinase, Ribosomal Protein L37a, Ribosomal Protein L7L1, RMND5B, RNF121, RNF130, RNF152, RNF185, RPS6KL1, RSBN1L, Rshl2b, Rtn-1, Salmonella flagella, SAMD12, SATL1, SCaMC-1, SCYL1, SgK223, SH2D6, SIMC1, Slap, SLC35A4, SLC43A1, Slfn2, Sm F, SPACA5, SPAG6, SPATA10, SPATA2L, SPDSY, SPZ1, SREC-II, SSAT, SSB-2, STK16, Supt4h1, Syndecan-4, TBCD, TCEANC, TCP11L1, TDRD6, TFIIA, THAP4, TIP120B, Tissue TGase, Tmem210, TRIM43C, TRIM74, TRPM6, TTC23, UNC5H3, VCY, VN1R2, WDR40B, WDR42B, ZCCHC9, ZDHHC1, ZFP260, Zimp7, ZNF140, ZNF191, ZNF192, ZNF2, ZNF224, ZNF268, ZNF285A, ZNF302, ZNF323, ZNF533, ZNF578, ZNF641, ZNF84, ZnT-7, ZSWIM2, and ZXDA.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Spermine, 1 g | sc-212953A | 1 g | $60.00 | |||
Spermine, 5 g | sc-212953 | 5 g | $192.00 | |||
Spermine, 25 g | sc-212953B | 25 g | $272.00 | |||
Spermine, 100 g | sc-212953C | 100 g | $883.00 |