Molecular structure of Spectinomycin dihydrochloride pentahydrate, CAS Number: 22189-32-8
Spectinomycin dihydrochloride pentahydrate (CAS 22189-32-8)
See product citations (9)
Alternate Names:
Spectinomycin dihydrochloride pentahydrate is also known as Togamycin.
Application:
Spectinomycin dihydrochloride pentahydrate is an aminocylcitol antibiotic isolated from Streptomyces spectabilis.
CAS Number:
22189-32-8
Purity:
≥95%
Molecular Weight:
495.35
Molecular Formula:
C14H24N2O7•2HCl•5H2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Spectinomycin dihydrochloride pentahydrate is an aminocylcitol antibiotic which is closely related to the aminoglycosides. Gram-positive and gram-negative Gonococcus spp. are reported to exhibit susceptibility to Spectinomycin dihydrochloride pentahydrate. Studies indicate that it interferes with peptidyl tRNA translocation thereby affecting protein synthesis in susceptible bacteria. Additional reports note that mutations in ribosomal proteins may prevent the binding of Spectinomycin dihydrochloride pentahydrate, thus potentially confering resistence to the compound. Additionally, Eschericia coli is reported to be reversibly inhibitied during growth and division by Spectinomycin dihydrochloride pentahydrate and that variations in bacterial sensitivity may be mediated by differences in ribosomes among different E. coli mutants.
Spectinomycin dihydrochloride pentahydrate (CAS 22189-32-8) References
- Removal of antibiotic resistance genes from transgenic tobacco plastids. | Iamtham, S. and Day, A. 2000. Nat Biotechnol. 18: 1172-6. PMID: 11062436
- In vivo selection of spectinomycin-binding RNAs. | Zimmerman, JM. and Maher, LJ. 2002. Nucleic Acids Res. 30: 5425-35. PMID: 12490711
- Sensitivity and Resistance to Spectinomycin in Escherichia coli. | Anderson, P. 1969. J Bacteriol. 100: 939-47. PMID: 16559073
- Efficacy of turkey herpesvirus vaccine when administered simultaneously with fowl pox vaccine. | Eidson, CS., et al. 1975. Poult Sci. 54: 1975-81. PMID: 180502
- Assessing the suitability of antibiotic resistance markers and the indirect ELISA technique for studying the competitive ability of selected Cyclopia Vent. rhizobia under glasshouse and field conditions in South Africa. | Spriggs, AC. and Dakora, FD. 2009. BMC Microbiol. 9: 142. PMID: 19619288
- Determination of water content by capillary gas chromatography coupled with thermal conductivity detection. | Lodi, A., et al. 2011. Pharmeur Bio Sci Notes. 2011: 40-4. PMID: 22225767
- Construction of a cyanobacterium synthesizing cyclopropane fatty acids. | Machida, S., et al. 2016. Biochim Biophys Acta. 1861: 980-987. PMID: 27263419
- Quorum sensing of microalgae associated marine Ponticoccus sp. PD-2 and its algicidal function regulation. | Chi, W., et al. 2017. AMB Express. 7: 59. PMID: 28281272
- Determination of spectinomycin dihydrochloride by liquid chromatography with electrochemical detection. | Elrod, L., et al. 1988. Pharm Res. 5: 664-7. PMID: 2977438
- Characterization of cyanobacterial cells synthesizing 10-methyl stearic acid. | Machida, S. and Suzuki, I. 2019. Photosynth Res. 139: 173-183. PMID: 29943360
- Spectinomycin: minimum inhibitory concentrations for Neisseria gonorrhoeae. | Porter, IA. and Wood, WJ. 1974. Br J Vener Dis. 50: 289-90. PMID: 4279027
- Isolation of a gene encoding a novel spectinomycin phosphotransferase from Legionella pneumophila. | Suter, TM., et al. 1997. Antimicrob Agents Chemother. 41: 1385-8. PMID: 9174205
- The selection in vivo and characterization of an RNA recognition motif for spectinomycin. | Thom, G. and Prescott, CD. 1997. Bioorg Med Chem. 5: 1081-6. PMID: 9222501
- Spectinomycin kinase from Legionella pneumophila. Characterization of substrate specificity and identification of catalytically important residues. | Thompson, PR., et al. 1998. J Biol Chem. 273: 14788-95. PMID: 9614079
Inhibitor of:
Cables2, LOC441617, MGC70857, SUMO-1, and VSTM2L.Activator of:
2810004N23Rik, 9130404H23Rik, AF-6, Ankyrin B, AtNOS1, C12orf60, C19orf25, C6orf35, Cables2, COL13A, Dbs, HEATR1, HOM-TES-103, KIAA0355, KIAA1826_8430410K20Rik, LOC144097_AI846148, LOC643669, MGC70857, MRP-S31, QIP1, Rab 3C, RAM, RGL3, SCAMP1, SCUBE1, SCUBE3, SH2D3A, SR-7, TMEM132D, VSTM2L, ZBED4, ZFHX4, and ZNF431.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Spectinomycin dihydrochloride pentahydrate, 5 g | sc-203279 | 5 g | $82.00 | |||
Spectinomycin dihydrochloride pentahydrate, 10 g | sc-203279A | 10 g | $120.00 |