Molecular structure of Sparfloxacin, CAS Number: 110871-86-8
Sparfloxacin (CAS 110871-86-8)
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Alternate Names:
Zagam
Application:
Sparfloxacin is a broad spectrum fluoroquinolone antibiotic
CAS Number:
110871-86-8
Purity:
≥98%
Molecular Weight:
392.40
Molecular Formula:
C19H22F2N4O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Sparfloxacin is a synthetic compound that belongs to the fluoroquinolone class of antibiotics. In research, sparfloxacin is used to study its mechanism of action, which involves inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication and transcription. This leads to the disruption of bacterial DNA processes and ultimately results in bacterial cell death. Research on sparfloxacin also includes investigations into its kinetics and the development of resistance mechanisms in bacteria. It is used in environmental microbiology to assess the impact of antibiotic contamination in various ecosystems and in studies examining the efficacy of wastewater treatment processes in removing such contaminants.
Sparfloxacin (CAS 110871-86-8) References
- In vitro activity of sparfloxacin compared with those of five other quinolones. | Cantón, E., et al. 1992. Antimicrob Agents Chemother. 36: 558-65. PMID: 1320362
- Sparfloxacin, ethambutol, and cortisol receptor inhibitor RU-40 555 treatment for disseminated Mycobacterium avium complex infection of normal C57BL/6 mice. | Perronne, C., et al. 1992. Antimicrob Agents Chemother. 36: 2408-12. PMID: 1336944
- Effects of sparfloxacin on CNS functions and urinary hydroxyproline in mice. | Bharal, N., et al. 2006. Pharmacol Res. 54: 111-7. PMID: 16701999
- Synthesis and structure-activity relationships of 5-substituted 6,8-difluoroquinolones, including sparfloxacin, a new quinolone antibacterial agent with improved potency. | Miyamoto, T., et al. 1990. J Med Chem. 33: 1645-56. PMID: 2342057
- In vitro and in vivo antibacterial activities of AT-4140, a new broad-spectrum quinolone. | Nakamura, S., et al. 1989. Antimicrob Agents Chemother. 33: 1167-73. PMID: 2802544
- Assessment of phototoxicity in pigmented Long-Evans rat: sparfloxacin and 8-methoxypsoralen. | Turnock, S., et al. 2018. Regul Toxicol Pharmacol. 92: 303-314. PMID: 29196029
- A novel Fe3O4/graphene oxide/citrus peel-derived bio-char based nanocomposite with enhanced adsorption affinity and sensitivity of ciprofloxacin and sparfloxacin. | Zhou, Y., et al. 2019. Bioresour Technol. 292: 121951. PMID: 31400654
- Sparfloxacin - Cu(II) - aromatic heterocyclic complexes: synthesis, characterization and in vitro anticancer evaluation. | Liu, QY., et al. 2022. Dalton Trans. 51: 9878-9887. PMID: 35713093
- Safe, Effective, and Inexpensive Clearance of Mycoplasma Contamination from Cultures of Apicomplexan Parasites with Sparfloxacin. | Malave-Ramos, DR., et al. 2022. Microbiol Spectr. 10: e0349722. PMID: 36190416
- In-vitro activity of sparfloxacin in comparison with currently available antimicrobials against respiratory tract pathogens. | Baquero, F. and Cantón, R. 1996. J Antimicrob Chemother. 37 Suppl A: 1-18. PMID: 8737121
- Sparfloxacin worldwide in vitro literature: isolate data available through 1994. | Cohen, MA., et al. 1996. Diagn Microbiol Infect Dis. 25: 53-64. PMID: 8882890
- Sparfloxacin but not levofloxacin or ofloxacin prolongs cardiac repolarization in rabbit Purkinje fibers. | Adamantidis, MM., et al. 1998. Fundam Clin Pharmacol. 12: 70-6. PMID: 9523187
- Chondrotoxicity and toxicokinetics of sparfloxacin in juvenile rats. | Stahlmann, R., et al. 1998. Antimicrob Agents Chemother. 42: 1470-5. PMID: 9624496
Inhibitor of:
Topo II.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sparfloxacin, 1 g | sc-202343 | 1 g | $45.00 | |||
Sparfloxacin, 5 g | sc-202343A | 5 g | $122.00 | |||
Sparfloxacin, 25 g | sc-202343B | 25 g | $469.00 | |||
Sparfloxacin, 100 g | sc-202343C | 100 g | $1775.00 |