Sparfloxacin is a fluoroquinolone with broad spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Inhibits bacterial DNA gyrase (topoisomerase). Effective against Mycobacterium tuberculosis. Shows photosensitizing effects. Sparfloxacin is an inhibitor of Topo II.
1. In vitro and in vivo antibacterial activities of AT-4140, a new broad-spectrum quinolone: S. Nakamura, et al.; Antimicrob. Agents Chemother. 33, 1167 (1989). 2. Synthesis and structure-activity relationships of 5-substituted 6,8-difluoroquinolones, inc
Soluble in water (<1 mg/ml), 100% ethanol, chloroform, methanol, and DMSO (9 mg/ml).
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Rated 5 out of
Beberok et alBeberok et al. (PubMed ID 25560573) found that Sparfloxacin inhibited melanogensis and changes in antioxidant enzymes in human melanocytes. -SCBT Publication Review
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