Molecular structure of Sp-Adenosine 3′,5′-cyclic monophosphorothioate triethylammonium salt, CAS Number: 93602-66-5
Sp-Adenosine 3′,5′-cyclic monophosphorothioate triethylammonium salt (CAS 93602-66-5)
Alternate Names:
Sp-Cyclic 3′,5′-hydrogen phosphorothioate adenosine; Sp-cAMPS triethylammonium salt
Application:
Sp-Adenosine 3′,5′-cyclic monophosphorothioate triethylammonium salt is a membrane permeable activator of cAMP dependent protein kinase I and II
CAS Number:
93602-66-5
Purity:
≥98%
Molecular Weight:
446.46
Molecular Formula:
C10H11N5O5PS•C6H16N
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Sp-Diastereomer of adenosine 3′,5′-cyclic monophosphorothioate is a potent, membrane-permeable activator of cAMP dependent protein kinase I and II that mimics the effects of cAMP as a second messenger in numerous systems while being resistant to cyclic nucleotide phosphodiesterases; exhibits greater specificity and affinity than forskolin and cAMP analogs such as dibutyryl-cAMP.
Sp-Adenosine 3′,5′-cyclic monophosphorothioate triethylammonium salt (CAS 93602-66-5) References
- Dopamine D4 receptor-induced postsynaptic inhibition of GABAergic currents in mouse globus pallidus neurons. | Shin, RM., et al. 2003. J Neurosci. 23: 11662-72. PMID: 14684868
- Chemically-induced long-term potentiation in rat motor cortex involves activation of extracellular signal-regulated kinase cascade. | Grzegorzewska, M., et al. 2004. Brain Res. 1021: 192-9. PMID: 15342267
- Egr-1 modulation of synapsin I expression: permissive effect of forskolin via cAMP. | James, AB., et al. 2004. Cell Signal. 16: 1355-62. PMID: 15381251
- Integration of steroid hormone initiated membrane action to genomic function in the brain. | Vasudevan, N., et al. 2005. Steroids. 70: 388-96. PMID: 15862822
- Dopamine receptor stimulation modulates AMPA receptor synaptic insertion in prefrontal cortex neurons. | Sun, X., et al. 2005. J Neurosci. 25: 7342-51. PMID: 16093384
- The midbrain periaqueductal gray and fear extinction: opioid receptor subtype and roles of cyclic AMP, protein kinase A, and mitogen-activated protein kinase. | McNally, GP., et al. 2005. Behav Neurosci. 119: 1023-33. PMID: 16187830
- Octopamine mediates thermal preconditioning of the locust ventilatory central pattern generator via a cAMP/protein kinase A signaling pathway. | Armstrong, GA., et al. 2006. J Neurosci. 26: 12118-26. PMID: 17122036
- The phosphorylation profile of protein kinase A substrates is modulated during Varicella-zoster virus infection. | Desloges, N., et al. 2008. Med Microbiol Immunol. 197: 353-60. PMID: 18066594
- Neurobiology of dysregulated motivational systems in drug addiction. | Edwards, S. and Koob, GF. 2010. Future Neurol. 5: 393-401. PMID: 20563312
- A key role for the phosphorylation of Ser440 by the cyclic AMP-dependent protein kinase in regulating the activity of the Src homology 2 domain-containing Inositol 5'-phosphatase (SHIP1). | Zhang, J., et al. 2010. J Biol Chem. 285: 34839-49. PMID: 20810657
- Physiology of the gonadotrophin-releasing hormone (GnRH) neurone: studies from embryonic GnRH neurones. | Constantin, S. 2011. J Neuroendocrinol. 23: 542-53. PMID: 21443528
- Adrenoceptor-mediated enhancement of interleukin-33 production by dendritic cells. | Yanagawa, Y., et al. 2011. Brain Behav Immun. 25: 1427-33. PMID: 21536121
- Differential regulation of synaptic and extrasynaptic α4 GABA(A) receptor populations by protein kinase A and protein kinase C in cultured cortical neurons. | Bohnsack, JP., et al. 2016. Neuropharmacology. 105: 124-132. PMID: 26767953
- P2Y12 Promotes Migration of Vascular Smooth Muscle Cells Through Cofilin Dephosphorylation During Atherogenesis. | Niu, X., et al. 2017. Arterioscler Thromb Vasc Biol. 37: 515-524. PMID: 28062501
Activator of:
Enzyme, Epac, and PKA.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sp-Adenosine 3′,5′-cyclic monophosphorothioate triethylammonium salt, 1 mg | sc-258176 | 1 mg | $143.00 |