Sox-5 Antibody (4H8): sc-293215
- Sox-5 Antibody (4H8) is a mouse monoclonal IgG2b κ Sox-5 antibody provided at 100 µg/ml
- raised against amino acids 181-230 of Sox-5 of human origin
- recommended for detection of Sox-5 of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Sox-5 Antibody (4H8). This work is in progress.
Sox-5 Antibody (4H8) is a mouse monoclonal IgG2b kappa light chain antibody that detects Sox-5 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Sox-5 (4H8) antibody is available as a non-conjugated format. Sox-5 protein plays a crucial role in regulating gene expression during development, particularly in various cell type differentiation. Sox-5 protein is primarily located in the nucleus, functioning as a transcription factor by binding to specific DNA sequences to modulate target gene transcription. Nuclear localization enables Sox-5 protein to interact with other transcriptional regulators and chromatin remodeling complexes, influencing developmental pathways and cellular processes. Sox gene family, including Sox-5, shows evolutionary conservation and involvement in critical biological functions, such as cell fate determination and developmental process regulation. Sox-5 protein dysregulation has been implicated in various human diseases, including developmental disorders and certain cancers, highlighting Sox-5′s importance in both normal physiology and disease states.
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Sox-5 Antibody (4H8) References:
- Identification of a novel Sry-related gene and its germ cell-specific expression. | Osaki, E., et al. 1999. Nucleic Acids Res. 27: 2503-10. PMID: 10359848
- Roles of Sox factors in neural determination: conserved signaling in evolution? | Sasai, Y. 2001. Int J Dev Biol. 45: 321-6. PMID: 11291862
- Electroporation-mediated transfer of SOX trio genes (SOX-5, SOX-6, and SOX-9) to enhance the chondrogenesis of mesenchymal stem cells. | Kim, HJ. and Im, GI. 2011. Stem Cells Dev. 20: 2103-14. PMID: 21401405
- Widening of the genetic and clinical spectrum of Lamb-Shaffer syndrome, a neurodevelopmental disorder due to SOX5 haploinsufficiency. | Zawerton, A., et al. 2020. Genet Med. 22: 524-537. PMID: 31578471
- Activation of the SOX-5, SOX-6, and SOX-9 Trio of Transcription Factors Using a Gene-Activated Scaffold Stimulates Mesenchymal Stromal Cell Chondrogenesis and Inhibits Endochondral Ossification. | Raftery, RM., et al. 2020. Adv Healthc Mater. 9: e1901827. PMID: 32329217
- SOX-5 activates a novel RORγt enhancer to facilitate experimental autoimmune encephalomyelitis by promoting Th17 cell differentiation. | Tian, Y., et al. 2021. Nat Commun. 12: 481. PMID: 33473108
- Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation. | Jing, Y., et al. 2023. Cell Stem Cell. 30: 1452-1471.e10. PMID: 37832549
- Enhanced Calvarial Bone Repair Using ASCs Engineered with RNA-Guided Split dCas12a System that Co-Activates Sox 5, Sox6, and Long Non-Coding RNA H19. | Nguyen, NTK., et al. 2024. Small. 20: e2306612. PMID: 38126683
- DNA binding and bending properties of the post-meiotically expressed Sry-related protein Sox-5. | Connor, F., et al. 1994. Nucleic Acids Res. 22: 3339-46. PMID: 8078769
- Ancestry and diversity of the HMG box superfamily. | Laudet, V., et al. 1993. Nucleic Acids Res. 21: 2493-501. PMID: 8506143
- Sox10, a novel transcriptional modulator in glial cells. | Kuhlbrodt, K., et al. 1998. J Neurosci. 18: 237-50. PMID: 9412504
- Characterisation and mapping of the human SOX14 gene. | Arsic, N., et al. 1998. Cytogenet Cell Genet. 83: 139-46. PMID: 9925951
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sox-5 Antibody (4H8) | sc-293215 | 100 µg/ml | $322.00 |