Sox-21 Antibody (2G10): sc-293461

Sox-21 Antibody (2G10) is a mouse monoclonal IgG2a kappa light chain antibody engineered to detect human Sox-21 protein with exceptional accuracy in a variety of applications, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Sox-21 monoclonal antibody (2G10) is raised against amino acids 224-265 of the partial length Sox-21 protein from human origin. Anti-Sox-21 antibody (2G10) exhibits strong species reactivity, effectively recognizing Sox-21 from mouse, rat, and human origins, making it a versatile tool for diverse research needs. Sox-21 protein, also called Sox25, is a member of the SRY-related HMG-box (Sox) family of transcription factors, characterized by the High-Mobility Group (HMG) domain that facilitates sequence-specific DNA binding and induces conformational changes in DNA structure, thereby regulating the transcription of target genes involved in cell fate determination and developmental processes. Sox-21 interacts with several key proteins, including co-activators such as CBP/p300, which enhance transcriptional activity, and repressors like Groucho/TLE, which modulate gene expression regulation. Sox-21 forms complexes with other transcription factors such as Pax-6 and Neuro D, which are crucial for neural development and differentiation. These protein-protein interactions are essential for Sox-21′s role in orchestrating complex gene regulatory networks that govern cellular differentiation, proliferation, and apoptosis during embryonic development and tissue homeostasis. Understanding the interactions between Sox-21 and binding partners is vital for elucidating the molecular mechanisms underlying developmental processes and disease states, including cancer and developmental disorders. Sox-21 monoclonal antibody (2G10) is available in a non-conjugated form, providing flexibility for various experimental setups, and serves as an indispensable tool for scientists aiming to elucidate the intricate regulatory networks governed by Sox-21.

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Sox-21 Antibody (2G10) References:

1. Identification of a novel Sry-related gene and its germ cell-specific expression.  |  Osaki, E., et al. 1999. Nucleic Acids Res. 27: 2503-10. PMID: 10359848
2. Roles of Sox factors in neural determination: conserved signaling in evolution?  |  Sasai, Y. 2001. Int J Dev Biol. 45: 321-6. PMID: 11291862
3. Ancestry and diversity of the HMG box superfamily.  |  Laudet, V., et al. 1993. Nucleic Acids Res. 21: 2493-501. PMID: 8506143
4. Sox10, a novel transcriptional modulator in glial cells.  |  Kuhlbrodt, K., et al. 1998. J Neurosci. 18: 237-50. PMID: 9412504
5. Characterisation and mapping of the human SOX14 gene.  |  Arsic, N., et al. 1998. Cytogenet Cell Genet. 83: 139-46. PMID: 9925951

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Sox-21 Antibody (2G10) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Sox-21 Antibody (2G10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Sox-21 Antibody (2G10) Specifications

Alternate Product Name: SOX21

Product Clone Name: 2G10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 224-265

Epitope Target: Sox-21

Epitope Species: human

Product Reactivity/Detection: Sox-21

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Sox-21 Antibody (2G10): N/A