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Sos SH3 domain inhibitor is a biologically active peptide. The SH3 binding sequence of Sos which blocks Sos/GRB2 interaction, preventing Ras activation via receptor protein tyrosine kinases.
1. Goudreau, N., et al., 1994. NMR structure of the N-terminal SH3 domain of GRB2 and its complex with a proline-rich peptide from Sos. Nature structural biology. 1(12): 898-907. PMID: 7773779
2. Li, N., et al., 1993. Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling. Nature. 363(6424): 85-8. PMID: 8479541
3. Vidal, M., et al., 2004. Design of peptoid analogue dimers and measure of their affinity for Grb2 SH3 domains. Biochemistry. 43(23): 7336-44. PMID: 15182177
4. Jacquot, Yves., et al., 2007. High affinity Grb2-SH3 domain ligand incorporating Cbeta-substituted prolines in a Sos-derived decapeptide. Bioorganic & medicinal chemistry. 15(3): 1439-47. PMID: 17113302
5. Ho, Pei-Yin., et al., 2006. Terbinafine inhibits endothelial cell migration through suppression of the Rho-mediated pathway. Molecular cancer therapeutics. 5(12): 3130-8. PMID: 17172416
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