Sos 1 Antibody (G-12): sc-376789
- Sos 1 Antibody (G-12) is a mouse monoclonal IgM κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 1301-1333 at the C-terminus of Sos 1 of human origin
- recommended for detection of Sos 1 p170 of mouse, rat, human and avian origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and equine, bovine and avian
- m-IgGκ BP-HRP is the preferred secondary detection reagent for Sos 1 Antibody (G-12) for WB and IHC(P) applications. This reagent is now offered in a bundle with Sos 1 Antibody (G-12) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
QUICK LINKS
Sos 1 Antibody (G-12) is a mouse monoclonal IgM antibody that detects Sos 1 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Sos 1 plays a crucial role as a guanine nucleotide exchange factor (GEF) that activates Ras proteins, which are pivotal in regulating cell growth, differentiation, and survival. The activation of Ras by Sos 1 is essential for the transmission of signals from cell surface receptors to downstream effectors, thereby influencing critical cellular processes such as proliferation and apoptosis. The interaction between Sos 1 and Ras is particularly important in the context of cancer, as aberrations in this signaling pathway can lead to uncontrolled cell division and tumorigenesis. Sos 1 is localized in the cytoplasm and can translocate to the plasma membrane upon activation, which is vital for signal transduction. Anti-Sos 1 antibody (G-12) enables researchers to gain insights into the dynamics of Ras signaling and its implications in various biological contexts, including developmental processes and disease states.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sos 1 Antibody (G-12) | sc-376789 | 200 µg/ml | $322.00 | |||
Sos 1 Antibody (G-12): m-IgGκ BP-HRP Bundle | sc-552146 | 200 µg Ab; 40 µg BP | $361.00 | |||
Sos 1 (G-12) Neutralizing Peptide | sc-376789 P | 100 µg/0.5 ml | $69.00 |