Sos 1 Antibody (25): sc-136235

Sos 1 Antibody (25) is a mouse monoclonal IgG1 antibody that detects Sos 1 in mouse, rat, human, and canine samples through applications such as western blotting (WB) and immunoprecipitation (IP). Sos 1 plays a crucial role as a guanine nucleotide-releasing factor, facilitating the activation of Ras proteins, which are pivotal in regulating various cellular processes, including growth, differentiation, and survival. The interaction between Sos 1 and Ras is essential for the transmission of signals from cell surface receptors to downstream effectors, thereby influencing critical pathways such as the MAP kinase signaling cascade. This pathway is vital for cellular responses to growth factors and other stimuli, making Sos 1 a key player in cellular signaling networks. Furthermore, Sos 1′s ability to interact with other proteins, such as the adapter protein GRB2, enhances its role in mediating signal transduction, underscoring its importance in both normal physiology and disease states, including cancer. Anti-Sos 1 antibody (25) is an invaluable tool for researchers aiming to explore the dynamics of Ras signaling and its implications in various biological contexts.

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Sos 1 Antibody (25) References:

1. Caenorhabditis elegans SOS-1 is necessary for multiple RAS-mediated developmental signals.  |  Chang, C., et al. 2000. EMBO J. 19: 3283-94. PMID: 10880441
2. An effector region in Eps8 is responsible for the activation of the Rac-specific GEF activity of Sos-1 and for the proper localization of the Rac-based actin-polymerizing machine.  |  Scita, G., et al. 2001. J Cell Biol. 154: 1031-44. PMID: 11524436
3. Phosphoinositide 3-kinase activates Rac by entering in a complex with Eps8, Abi1, and Sos-1.  |  Innocenti, M., et al. 2003. J Cell Biol. 160: 17-23. PMID: 12515821
4. Abl-dependent tyrosine phosphorylation of Sos-1 mediates growth-factor-induced Rac activation.  |  Sini, P., et al. 2004. Nat Cell Biol. 6: 268-74. PMID: 15039778
5. Abelson interacting protein 1 (Abi-1) is essential for dendrite morphogenesis and synapse formation.  |  Proepper, C., et al. 2007. EMBO J. 26: 1397-409. PMID: 17304222
6. [New findings in Noonan syndrome and Leopard syndrome: activating mutations in RAF-1 and SOS-1].  |  Dereure, O. 2008. Ann Dermatol Venereol. 135: 624-5. PMID: 18789305
7. Analysis of mutations in the SOS-1 gene in two Polish families with hereditary gingival fibromatosis.  |  Gawron, K., et al. 2017. Oral Dis. 23: 983-989. PMID: 28425619
8. Prior Gemtuzumab Ozogamicin Exposure in Adults with Acute Myeloid Leukemia Does Not Increase Hepatic Veno-Occlusive Disease Risk after Allogeneic Hematopoietic Cell Transplantation: A Center for International Blood and Marrow Transplant Research Analysis.  |  Ho, VT., et al. 2020. Biol Blood Marrow Transplant. 26: 884-892. PMID: 31891815
9. Clinics and genetic background of hereditary gingival fibromatosis.  |  Strzelec, K., et al. 2021. Orphanet J Rare Dis. 16: 492. PMID: 34819125
10. Combining SOS1 and MEK Inhibitors in a Murine Model of Plexiform Neurofibroma Results in Tumor Shrinkage.  |  Jackson, M., et al. 2023. J Pharmacol Exp Ther. 385: 106-116. PMID: 36849412

The preferred Sos 1 antibody is Sos 1 Antibody (A-9): sc-17793.