Sordarin sodium salt (CAS 463356-00-5)
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An antifungal metabolite possessing a tetracyclic diterpene glycoside structure. It is a highly potent inhibitor of eukaryotic protein synthesis with selectivity for the fungal translation machinery. The mode of action of sordarin is unique; it selectively targets the elongation factor 2 (EF2) in fungi, which is essential for protein synthesis. By binding to EF2, sordarin disrupts the translocation step in protein elongation, effectively halting fungal growth without affecting mammalian cells, which have a structurally different EF2. The sodium salt form of sordarin enhances its solubility in aqueous solutions, potentially improving its bioavailability and making it more amenable for use in various experimental formulations.
Sordarin sodium salt (CAS 463356-00-5) References
- The amidation step of diphthamide biosynthesis in yeast requires DPH6, a gene identified through mining the DPH1-DPH5 interaction network. | Uthman, S., et al. 2013. PLoS Genet. 9: e1003334. PMID: 23468660
- Insights into diphthamide, key diphtheria toxin effector. | Abdel-Fattah, W., et al. 2013. Toxins (Basel). 5: 958-68. PMID: 23645155
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sordarin sodium salt, 5 mg | sc-253601 | 5 mg | $557.00 |