Molecular structure of Sofalcone
Sofalcone (CAS 64506-49-6)
Alternate Names:
Solon
CAS Number:
64506-49-6
Molecular Weight:
450.52
Molecular Formula:
C27H30O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Sofalcone is thought to work by influencing the activity of different proteins and enzymes that play a role in cell signaling pathways. Furthermore, it has demonstrated the ability to hinder the generation of reactive oxygen species and eliminate free radicals. Studies have revealed that sofalcone effectively modulates the expression of various proteins and enzymes involved in cell signaling pathways while also exerting its antioxidant properties by inhibiting reactive oxygen species production and scavenging free radicals.
Sofalcone (CAS 64506-49-6) References
- Autonomic nervous regeneration in acetic acid-induced ulcer from the viewpoint of synapse formation--effect of basic fibroblast growth factor and sofalcone in the rat. | Nakamura, M., et al. 2000. Aliment Pharmacol Ther. 14 Suppl 1: 50-7. PMID: 10807403
- The effect of sofalcone on indomethacin-induced gastric ulcers in a Helicobacter pylori-infected gnotobiotic murine model. | Kabir, AM., et al. 2000. Aliment Pharmacol Ther. 14 Suppl 1: 223-9. PMID: 10807428
- Sofalcone, a mucoprotective agent, increases the cure rate of Helicobacter pylori infection when combined with rabeprazole, amoxicillin and clarithromycin. | Isomoto, H., et al. 2005. World J Gastroenterol. 11: 1629-33. PMID: 15786539
- Sofalcone, an anti-ulcer chalcone derivative, suppresses inflammatory crosstalk between macrophages and adipocytes and adipocyte differentiation: implication of heme-oxygenase-1 induction. | Tanaka, H., et al. 2009. Biochem Biophys Res Commun. 381: 566-71. PMID: 19239904
- Quantification of sofalcone in human plasma and urine by high performance liquid chromatography-mass spectrometry. | Wang, L., et al. 2011. J Pharm Biomed Anal. 55: 1179-85. PMID: 21530127
- Sofalcone upregulates the nuclear factor (erythroid-derived 2)-like 2/heme oxygenase-1 pathway, reduces soluble fms-like tyrosine kinase-1, and quenches endothelial dysfunction: potential therapeutic for preeclampsia. | Onda, K., et al. 2015. Hypertension. 65: 855-62. PMID: 25667213
- Irsogladine maleate, a gastric mucosal protectant, suppresses intestinal polyp development in Apc-mutant mice. | Onuma, W., et al. 2016. Oncotarget. 7: 8640-52. PMID: 26840084
- Risk of post-stroke pneumonia with proton pump inhibitors, H2 receptor antagonists and mucoprotective agents: A retrospective nationwide cohort study. | Song, TJ. and Kim, J. 2019. PLoS One. 14: e0216750. PMID: 31067267
- Sofalcone, a gastroprotective drug, covalently binds to KEAP1 to activate Nrf2 resulting in anti-colitic activity. | Kim, W., et al. 2019. Eur J Pharmacol. 865: 172722. PMID: 31614142
- Effect of sofalcone on gastric mucous glycoprotein in experimental gastritis induced by sodium taurocholate. | Murakami, S., et al. 1988. Res Commun Chem Pathol Pharmacol. 62: 461-82. PMID: 3222525
- Design, synthesis, and evaluation of amphiphilic sofalcone derivatives as potent Gram-positive antibacterial agents. | Lin, S., et al. 2020. Eur J Med Chem. 202: 112596. PMID: 32659547
- The NSP14/NSP10 RNA repair complex as a Pan-coronavirus therapeutic target. | Rona, G., et al. 2022. Cell Death Differ. 29: 285-292. PMID: 34862481
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sofalcone, 1 g | sc-471045 | 1 g | $342.00 |