Molecular structure of Sodium oxamate, CAS Number: 565-73-1
Sodium oxamate (CAS 565-73-1)
See product citations (14)
Alternate Names:
Oxamic Acid Sodium Salt; Aminooxoacetic acid sodium salt; Oxalic acid monoamide sodium salt
Application:
Sodium oxamate is an inhibitor of gluconeogenesis useful for anticancer research
CAS Number:
565-73-1
Purity:
≥98%
Molecular Weight:
111.03
Molecular Formula:
C2H2NO3•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Sodium oxamate is an inhibitor of gluconeogenesis and glycolysis. It is a structural analog of pyruvate, inhibits LDH (L(+)-lactate dehydrogenase) and derails the entire gluconeogenic pathway. It can inhibit the activity of glycolytic enzymes and is used in a variety of research applications, including biochemical and physiological studies. As cancer cells are often dependent on glycolysis for ATP production, sodium oxamate has implications as an anticancer compound.
Sodium oxamate (CAS 565-73-1) References
- Lactate dehydrogenase-C4 is involved in heparin- and NADH-dependent bovine sperm capacitation. | O'Flaherty, CM., et al. 2002. Andrologia. 34: 91-7. PMID: 11966575
- Acrosome reaction in bovine spermatozoa: role of reactive oxygen species and lactate dehydrogenase C4. | O'Flaherty, C., et al. 2005. Biochim Biophys Acta. 1726: 96-101. PMID: 16112812
- Alkalizing reactions streamline cellular metabolism in acidogenic microorganisms. | Arioli, S., et al. 2010. PLoS One. 5: e15520. PMID: 21152088
- Lactate dehydrogenase C and energy metabolism in mouse sperm. | Odet, F., et al. 2011. Biol Reprod. 85: 556-64. PMID: 21565994
- Interference with the mitochondrial bioenergetics fuels reprogramming to pluripotency via facilitation of the glycolytic transition. | Son, MJ., et al. 2013. Int J Biochem Cell Biol. 45: 2512-8. PMID: 23939289
- Oxamate-mediated inhibition of lactate dehydrogenase induces protective autophagy in gastric cancer cells: involvement of the Akt-mTOR signaling pathway. | Zhao, Z., et al. 2015. Cancer Lett. 358: 17-26. PMID: 25524555
- Metabolic reprogramming enables hepatocarcinoma cells to efficiently adapt and survive to a nutrient-restricted microenvironment. | Cassim, S., et al. 2018. Cell Cycle. 17: 903-916. PMID: 29633904
- Lactate dehydrogenase supports lactate oxidation in mitochondria isolated from different mouse tissues. | Young, A., et al. 2020. Redox Biol. 28: 101339. PMID: 31610469
- Combination of Metformin, Sodium Oxamate and Doxorubicin Induces Apoptosis and Autophagy in Colorectal Cancer Cells via Downregulation HIF-1α. | Coronel-Hernández, J., et al. 2021. Front Oncol. 11: 594200. PMID: 34123772
- Oxamate, an inhibitor of lactate dehydrogenase, can stimulate M2 polarization of peritoneal macrophages in mice with Lewis lung carcinoma. | Solyanik, GI., et al. 2021. Exp Oncol. 43: 270-273. PMID: 34591427
- Sodium oxamate reduces lactate production to improve the glucose homeostasis of Micropterus salmoides fed high-carbohydrate diets. | Shen, HC., et al. 2023. Am J Physiol Regul Integr Comp Physiol. 324: R227-R241. PMID: 36572554
- Inhibition by potential metabolic inhibitors of in vitro adipose tissue lipogenesis. | Hood, RL., et al. 1985. Comp Biochem Physiol B. 81: 667-70. PMID: 4028683
- Energy sources for protein synthesis and enzymatic secretion in rat pancreas in vitro. | Bauduin, H., et al. 1969. Biochim Biophys Acta. 174: 722-33. PMID: 5776194
Inhibitor of:
γ-GCSc, BDH1, CTBS, DMGDH, Enzyme, FAHD1, FucU, G3PP, GLYATL1, GLYCTK, LDH, LDH-D, LDHA, LDHB, LDHC, and ME2.Activator of:
EG433182, and L-Lactate Dehydrogenase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sodium oxamate, 5 g | sc-215880 | 5 g | $77.00 | |||
Sodium oxamate, 25 g | sc-215880A | 25 g | $152.00 | |||
Sodium oxamate, 100 g | sc-215880B | 100 g | $469.00 | |||
Sodium oxamate, 250 g | sc-215880C | 250 g | $1106.00 | |||
Sodium oxamate, 1 kg | sc-215880D | 1 kg | $4111.00 |