Date published: 2026-4-5

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Sodium nitroprusside dihydrate (CAS 13755-38-9)

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Alternate Names:
Sodium nitroferricyanide(III) dihydrate
Application:
Sodium nitroprusside dihydrate is a nitric oxide releasing compound
CAS Number:
13755-38-9
Purity:
≥98%
Molecular Weight:
297.95
Molecular Formula:
C5FeN6O•2Na•2H2O
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Sodium nitroprusside dihydrate, is a nitric oxide donor/releaser and potent vasodilator, which has been reported to reduce lipid peroxidation-induced membrane damage, and is believed to exert its vasodilating activity through the vascular activation of nitric oxide. Sodium nitroprusside dihydrate is useful for quantitative ammonium analysis, as well as chromatographic detection of cystine-containing peptides. It has also been reported to be beneficial in maintaining post-thaw sperm viability and motion for up to 6 hours, which has been attributed to the reduction of lipid peroxidative damage to the sperm membrane substances.


Sodium nitroprusside dihydrate (CAS 13755-38-9) References

  1. Infrared evidence of NO linkage photoisomerization in Na2[Fe(CN)5NO].2H2O at low temperature: experimental and theoretical (DFT) isotopic shifts from 15n(O), 18O and 54Fe species.  |  Chacón Villalba, ME., et al. 2001. Spectrochim Acta A Mol Biomol Spectrosc. 57: 367-73. PMID: 11206572
  2. Release of hepatocyte growth factor from mechanically stretched skeletal muscle satellite cells and role of pH and nitric oxide.  |  Tatsumi, R., et al. 2002. Mol Biol Cell. 13: 2909-18. PMID: 12181355
  3. Hsp70 prevents nitric oxide-induced apoptosis in articular chondrocytes.  |  Terauchi, R., et al. 2003. Arthritis Rheum. 48: 1562-8. PMID: 12794824
  4. Identification of possible mediators of embryonic mortality caused by mastitis: actions of lipopolysaccharide, prostaglandin F2alpha, and the nitric oxide generator, sodium nitroprusside dihydrate, on oocyte maturation and embryonic development in cattle.  |  Soto, P., et al. 2003. Am J Reprod Immunol. 50: 263-72. PMID: 14629032
  5. Metabolic activation of sodium nitroprusside to nitric oxide in vascular smooth muscle.  |  Kowaluk, EA., et al. 1992. J Pharmacol Exp Ther. 262: 916-22. PMID: 1527732
  6. Glutamine protects articular chondrocytes from heat stress and NO-induced apoptosis with HSP70 expression.  |  Tonomura, H., et al. 2006. Osteoarthritis Cartilage. 14: 545-53. PMID: 16480901
  7. Tumor necrosis factor-alpha protects synovial cells from nitric oxide induced apoptosis through phosphoinositide 3-kinase Akt signal transduction.  |  Chen, Q., et al. 2006. J Rheumatol. 33: 1061-8. PMID: 16755653
  8. Anion-anion assembly in crystal of sodium nitroprusside.  |  Nelyubina, YV., et al. 2008. J Phys Chem A. 112: 8790-6. PMID: 18729437
  9. Nitric oxide (NO) reversed TNF-α inhibition of trophoblast interaction with endothelial cellular networks.  |  Xu, B., et al. 2014. Placenta. 35: 417-21. PMID: 24695240
  10. Construction of supramolecular hydrogels using photo-generated nitric oxide radicals.  |  Mulvee, M., et al. 2018. Soft Matter. 14: 5950-5954. PMID: 30010173
  11. Involvement of a Response Regulator VdSsk1 in Stress Response, Melanin Biosynthesis and Full Virulence in Verticillium dahliae.  |  Zheng, J., et al. 2019. Front Microbiol. 10: 606. PMID: 30967857
  12. Nitric oxide plays a crucial role in midgut immunity under microsporidian infection in Antheraea pernyi.  |  Liu, W., et al. 2020. Mol Immunol. 126: 65-72. PMID: 32768860
  13. Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates.  |  Ignarro, LJ., et al. 1981. J Pharmacol Exp Ther. 218: 739-49. PMID: 6115052
  14. Effect of sodium nitroprusside on sperm motility, viability, and lipid peroxidation.  |  Hellstrom, WJ., et al. 1994. Fertil Steril. 61: 1117-22. PMID: 8194627

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Sodium nitroprusside dihydrate, 1 g

sc-203395
1 g
$43.00

Sodium nitroprusside dihydrate, 5 g

sc-203395A
5 g
$85.00

Sodium nitroprusside dihydrate, 100 g

sc-203395B
100 g
$158.00