Date published: 2025-10-13

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Sodium Fluoride (CAS 7681-49-4)

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Alternate Names:
Pediaflor; Zymafluor
Application:
Sodium Fluoride is an inhibitor of serine/threonine phosphatases widely used in bone and dental research
CAS Number:
7681-49-4
Purity:
≥99%
Molecular Weight:
41.99
Molecular Formula:
NaF
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.

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Sodium Fluoride is utilized in biochemical research for its role as an enzyme inhibitor, particularly in studies involving phosphatases. This inhibition is for exploring regulatory mechanisms within cellular signaling pathways where phosphate groups play a key role. Additionally, Sodium Fluoride is used in dental research due to its affinity for calcium, which helps in the study of mineralization and demineralization processes in teeth. In metabolic studies, Sodium Fluoride serves to investigate glycolysis, as it inhibits enolase—an enzyme critical for the breakdown of carbohydrates. Furthermore, its application extends to the preservation of biological samples, where it inhibits enzymatic degradation, thereby maintaining the integrity of the sample for further analysis.


Sodium Fluoride (CAS 7681-49-4) References

  1. Association of heterotrimeric G-proteins with bovine aortic phospholipase C gamma.  |  Hodson, EA., et al. 1999. Biochem Biophys Res Commun. 258: 425-30. PMID: 10329403
  2. Time-dependent dephosphorylation through serine/threonine phosphatases is required for stable adhesion of highly and poorly metastatic HT-29 colon carcinoma cell lines to collagen.  |  Haier, J. and Nicolson, GL. 2000. Anticancer Res. 20: 2265-71. PMID: 10953284
  3. The role of Ca2+ mobilization and heterotrimeric G protein activation in mediating tyrosine phosphorylation signaling patterns in vascular smooth muscle cells.  |  Sayeski, PP., et al. 2000. Mol Cell Biochem. 212: 91-8. PMID: 11108140
  4. Protein phosphatases 1 and 2A promote Raf-1 activation by regulating 14-3-3 interactions.  |  Jaumot, M. and Hancock, JF. 2001. Oncogene. 20: 3949-58. PMID: 11494123
  5. Mechanisms of sodium fluoride-induced endothelial cell barrier dysfunction: role of MLC phosphorylation.  |  Wang, P., et al. 2001. Am J Physiol Lung Cell Mol Physiol. 281: L1472-83. PMID: 11704544
  6. Sodium fluoride is a less efficient human cell mutagen at low concentrations.  |  Crespi, CL., et al. 1990. Environ Mol Mutagen. 15: 71-7. PMID: 2307151
  7. High concentration aqueous sodium fluoride certified reference materials for forensic use certified by complexometric titration.  |  Archer, M., et al. 2015. Anal Bioanal Chem. 407: 3205-9. PMID: 25326884
  8. Sodium fluoride induces apoptosis in mouse splenocytes by activating ROS-dependent NF-κB signaling.  |  Deng, H., et al. 2017. Oncotarget. 8: 114428-114441. PMID: 29383091
  9. Intentional Toxic Ingestion of Sodium Fluoride: A Case Report.  |  Bridwell, RE., et al. 2019. Cureus. 11: e5025. PMID: 31497452
  10. In situ structural modification of bacterial cellulose by sodium fluoride.  |  Sun, B., et al. 2020. Carbohydr Polym. 231: 115765. PMID: 31888807
  11. Sodium fluoride or sodium monofluorophosphate? A critical view of a meta-analysis on their relative effectiveness in dentifrices.  |  Holloway, PJ. and Worthington, HV. 1993. Am J Dent. 6 Spec No: S55-8. PMID: 7488357
  12. Chemical agents for the control of plaque and plaque microflora: an overview.  |  Gaffar, A., et al. 1997. Eur J Oral Sci. 105: 502-7. PMID: 9395116
  13. Testing the potential of sodium fluoride to affect spermatogenesis in the rat.  |  Sprando, RL., et al. 1997. Food Chem Toxicol. 35: 881-90. PMID: 9409628
  14. Addition of sodium fluoride to whole blood does not stabilize plasma homocysteine but produces dilution effects on plasma constituents and hematocrit.  |  Hughes, MP., et al. 1998. Clin Chem. 44: 2204-6. PMID: 9761260
  15. Heterotrimeric G proteins as fluoride targets in bone (review).  |  Susa, M. 1999. Int J Mol Med. 3: 115-26. PMID: 9917518

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Sodium Fluoride, 5 g

sc-24988A
5 g
$39.00
US: Only available in the US

Sodium Fluoride, 100 g

sc-24988
100 g
$45.00
US: Only available in the US

Sodium Fluoride, 500 g

sc-24988B
500 g
$98.00
US: Only available in the US