Date published: 2026-4-25

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Sodium chlorofluoroacetate (CAS 70395-35-6)

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CAS Number:
70395-35-6
Molecular Weight:
134.47
Molecular Formula:
C2HClFNaO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Sodium chlorofluoroacetate (CF3COONa) is a versatile synthetic compound with diverse applications, ranging from insecticides to laboratory experiments. This organofluorine compound is characterized by the presence of both carbon and fluorine atoms, along with chlorine atoms. Sodium chlorofluoroacetate exists as a colorless, crystalline solid that readily dissolves in water and organic solvents. Its primary role lies in its effectiveness as an insecticide. However, it has also found utility in the synthesis of organic compounds and serves as a valuable reagent in laboratory experiments. Scientific research has extensively employed sodium chlorofluoroacetate for various purposes. Its applications span from being a reagent in organic synthesis, a catalyst in chemical reactions, to a solvent in chromatographic separations. Sodium chlorofluoroacetate has further proven valuable in exploring enzyme kinetics and protein folding. While the precise mechanism of action of sodium chlorofluoroacetate remains incompletely understood, it is recognized as an inhibitor of specific enzymes and disruptor of certain compound metabolism. It is believed to bind to particular enzymes, impeding their normal functions. Furthermore, it is postulated to interfere with the transportation of specific compounds across cell membranes.


Sodium chlorofluoroacetate (CAS 70395-35-6) References

  1. Fragment-Based Discovery of Irreversible Covalent Inhibitors of Cysteine Proteases Using Chlorofluoroacetamide Library.  |  Miura, C., et al. 2020. Chem Pharm Bull (Tokyo). 68: 1074-1081. PMID: 33132374
  2. The war on hTG2: warhead optimization in small molecule human tissue transglutaminase inhibitors.  |  Mader, L., et al. 2023. RSC Med Chem. 14: 277-298. PMID: 36846370
  3. Fluorocarbohydrates. XIV. Reaction of N-(2-chloro-1,1,2-trifluoroethyl)diethylamine with some O-isopropylidene sugars.  |  Wood, KR., et al. 1966. J Chem Soc Perkin 1. 21: 1994-7. PMID: 5950809
  4. Vibrational assignment, normal-coordinate analysis, and vibrational optical activity of chlorofluoroacetic acid and chlorofluoroacetate  |  J. Calienni, J. B. Trager, M. A. Davies, U. Gunnia, and M. Diem. 1989,. J. Phys. Chem. 93, 13,: 5049–5055.
  5. Synthesis and Gas-Separation Properties of New Silacyclopentane-Containing Polynorbornenes  |  V. A. Zhigarev, A. A. Morontsev, R. Yu. Nikiforov, M. L. Gringolts, N. A. Belov, N. G. Komalenkova, V. G. Lakhtin & E. Sh. Finkelshtein. 2019). Polymer Science, Series C. volume 61,: pages107–119 (.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Sodium chlorofluoroacetate, 2.5 g

sc-331792
2.5 g
$131.00

Sodium chlorofluoroacetate, 10 g

sc-331792A
10 g
$384.00