Date published: 2025-9-10

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Sodium Butyrate (CAS 156-54-7)

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Alternate Names:
Sodium Butyrate also known as Butyric acid sodium salt; Butanoicacidsodiumsalt butyratesodium; sodiumpropanecarboxylate
Application:
Sodium Butyrate is an HDAC inhibitor, apoptosis inducer and can induce differentiation and gene expression and also prevent cell proliferation
CAS Number:
156-54-7
Purity:
≥98%
Molecular Weight:
110.09
Molecular Formula:
C4H7O2Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Sodium Butyrate has been reported to cause hyperacetylation of histones due to its role as a histone deacetylase (HDAC) inhibitor (IC50 values are 0.3, 0.4, 0.3, mM for HDAC1, 2 and 7 respectively). Sodium Butyrate may act to cause induction of differentiation and gene expression and also prevent cell proliferation. Mechanistic studies suggest that the action of Sodium Butyrate is often mediated through Sp1/Sp3-associated HDAC activity which leads to transcriptional activation of the p21 gene. Additionally Sodium Butyrate demonstrates the ability to downregulate numerous genes associated with cytokine signaling, specifically, the IFN-gamma (interferon gamma) pathway.


Sodium Butyrate (CAS 156-54-7) References

  1. Inhibition of histone deacetylase activity by butyrate.  |  Davie, JR. 2003. J Nutr. 133: 2485S-2493S. PMID: 12840228
  2. Expression profiling of sodium butyrate (NaB)-treated cells: identification of regulation of genes related to cytokine signaling and cancer metastasis by NaB.  |  Joseph, J., et al. 2004. Oncogene. 23: 6304-15. PMID: 15318170
  3. Competitive inhibition of histone deacetylase activity by trichostatin A and butyrate.  |  Sekhavat, A., et al. 2007. Biochem Cell Biol. 85: 751-8. PMID: 18059533
  4. Sodium butyrate attenuated neuronal apoptosis via GPR41/Gβγ/PI3K/Akt pathway after MCAO in rats.  |  Zhou, Z., et al. 2021. J Cereb Blood Flow Metab. 41: 267-281. PMID: 32151222
  5. Sodium Butyrate Alleviates Mouse Colitis by Regulating Gut Microbiota Dysbiosis.  |  Dou, X., et al. 2020. Animals (Basel). 10: PMID: 32645998
  6. Sodium butyrate protects against lipopolysaccharide-induced liver injury partially via the GPR43/ β-arrestin-2/NF-κB network.  |  Luo, QJ., et al. 2021. Gastroenterol Rep (Oxf). 9: 154-165. PMID: 34026223
  7. Prebiotic Inulin and Sodium Butyrate Attenuate Obesity-Induced Intestinal Barrier Dysfunction by Induction of Antimicrobial Peptides.  |  Beisner, J., et al. 2021. Front Immunol. 12: 678360. PMID: 34177920
  8. Sodium Butyrate Alleviates Intestinal Inflammation in Mice with Necrotizing Enterocolitis.  |  Sun, Q., et al. 2021. Mediators Inflamm. 2021: 6259381. PMID: 34675753
  9. Supplementation with sodium butyrate protects against antibiotic-induced increases in ethanol consumption behavior in mice.  |  Reyes, RE., et al. 2022. Alcohol. 100: 1-9. PMID: 34999234
  10. Sodium Butyrate Ameliorates Oxidative Stress-Induced Intestinal Epithelium Barrier Injury and Mitochondrial Damage through AMPK-Mitophagy Pathway.  |  Li, X., et al. 2022. Oxid Med Cell Longev. 2022: 3745135. PMID: 35132348
  11. Enhancing effect of sodium butyrate on phosphatidylserine-liposome-induced macrophage polarization.  |  Wu, L., et al. 2022. Inflamm Res. 71: 641-652. PMID: 35347345
  12. Sodium butyrate modulates blood pressure and gut microbiota in maternal tryptophan-free diet-induced hypertension rat offspring.  |  Hsu, CN., et al. 2022. J Nutr Biochem. 108: 109090. PMID: 35724813
  13. Sodium butyrate administration modulates the ruminal villus height, inflammation-related gene expression, and plasma hormones concentration in dry cows fed a high-fiber diet.  |  Fukumori, R., et al. 2022. Anim Sci J. 93: e13791. PMID: 36478496
  14. Sodium Butyrate Attenuates AGEs-Induced Oxidative Stress and Inflammation by Inhibiting Autophagy and Affecting Cellular Metabolism in THP-1 Cells.  |  Yan, M., et al. 2022. Molecules. 27: PMID: 36557849
  15. The effect of sodium butyrate on histone modification.  |  Sealy, L. and Chalkley, R. 1978. Cell. 14: 115-21. PMID: 667928

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Sodium Butyrate, 250 mg

sc-202341
250 mg
$30.00

Sodium Butyrate, 5 g

sc-202341B
5 g
$46.00

Sodium Butyrate, 25 g

sc-202341A
25 g
$82.00

Sodium Butyrate, 500 g

sc-202341C
500 g
$218.00