Superoxide Dismutase 2/SOD2 Antibody (24): sc-130346

SOD-2 Antibody (24) is a mouse monoclonal IgG1 kappa light chain antibody specifically raised against recombinant human Superoxide Dismutase 2 (SOD2), an essential mitochondrial enzyme critical for protecting cells from oxidative damage by catalyzing the conversion of the superoxide anion into hydrogen peroxide and oxygen. SOD2, also known as manganese superoxide dismutase (MnSOD), is synthesized in the cytosol and posttranslationally transported into the mitochondrial matrix, where SOD2 plays a pivotal role in cellular defense mechanisms against reactive oxygen species (ROS). SOD2′s mitochondrial location is particularly important, as this organelle is a major source of ROS during cellular respiration, and SOD2′s activity ensures the mitigation of oxidative stress that could otherwise lead to mitochondrial dysfunction and subsequent cellular damage. Dysfunction or mutations in the SOD2 gene have been implicated in several pathological conditions, including neurodegenerative diseases such as Alzheimer′s and Parkinson′s, ischemic heart disease, and idiopathic dilated cardiomyopathy. Studies in animal models have demonstrated the critical role of SOD2, with homozygous mutant mice exhibiting severe oxidative damage, dilated cardiomyopathy, and metabolic abnormalities. Anti-SOD-2 antibody (24) is validated for use in western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA), providing researchers with a reliable tool for studying the function and regulation of this indispensable mitochondrial enzyme.

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Superoxide Dismutase 2/SOD2 Antibody (24) References:

1. Sirt3 Impairment and SOD2 Hyperacetylation in Vascular Oxidative Stress and Hypertension.  |  Dikalova, AE., et al. 2017. Circ Res. 121: 564-574. PMID: 28684630
2. There is no relationship between SOD2 Val-16Ala polymorphism and breast cancer risk or survival.  |  Wang, C., et al. 2017. Mol Clin Oncol. 7: 579-590. PMID: 29046792
3. Insights into the Dichotomous Regulation of SOD2 in Cancer.  |  Kim, YS., et al. 2017. Antioxidants (Basel). 6: PMID: 29099803
4. SOD2, a Potential Transcriptional Target Underpinning CD44-Promoted Breast Cancer Progression.  |  Alateyah, N., et al. 2022. Molecules. 27: PMID: 35164076
5. Heterozygous SOD2 deletion selectively impairs SERCA function in the soleus of female mice.  |  Braun, JL., et al. 2022. Physiol Rep. 10: e15285. PMID: 35581738
6. Angelica sinensis polysaccharide improves mitochondrial metabolism of osteoarthritis chondrocytes through PPARγ/SOD2/ROS pathways.  |  Ni, S., et al. 2023. Phytother Res. 37: 5394-5406. PMID: 37632225
7. Nimbolide Inhibits SOD2 to Control Pancreatic Ductal Adenocarcinoma Growth and Metastasis.  |  Mehmetoglu-Gurbuz, T., et al. 2023. Antioxidants (Basel). 12: PMID: 37891871
8. The mitochondrial protein Sod2 is important for the migration, maintenance, and fitness of germ cells.  |  Tarbashevich, K., et al. 2023. Front Cell Dev Biol. 11: 1250643. PMID: 37954204
9. SOD2 promotes the immunosuppressive function of mesenchymal stem cells at the expense of adipocyte differentiation.  |  Li, Y., et al. 2024. Mol Ther. 32: 1144-1157. PMID: 38310354
10. SOD2 orchestrates redox homeostasis in intervertebral discs: A novel insight into oxidative stress-mediated degeneration and therapeutic potential.  |  Tamagawa, S., et al. 2024. Redox Biol. 71: 103091. PMID: 38412803

The preferred Superoxide Dismutase 2/SOD2 antibody is Superoxide Dismutase 2/SOD2 Antibody (A-2): sc-133134.